Lineage for Family d.3.1.1: Papain-like

  1. Root: SCOPe 2.06
  2. 2152203Class d: Alpha and beta proteins (a+b) [53931] (385 folds)
  3. 2154577Fold d.3: Cysteine proteinases [54000] (1 superfamily)
    consists of one alpha-helix and 4 strands of antiparallel beta-sheet and contains the catalytic triad Cys-His-Asn
  4. 2154578Superfamily d.3.1: Cysteine proteinases [54001] (24 families) (S)
    the constitute families differ by insertion into and circular permutation of the common catalytic core made of one alpha-helix and 3-strands of beta-sheet
  5. 2154579Family d.3.1.1: Papain-like [54002] (26 protein domains)

Protein Domains:

  1. 2154580(Pro)cathepsin B [54022] (3 species)
    1. 2154581Species Cow (Bos taurus) [TaxId:9913] [54025] (3 PDB entries)
    2. 2154585Species Human (Homo sapiens) [TaxId:9606] [54023] (6 PDB entries)
    3. 2154596Species Norway rat (Rattus norvegicus) [TaxId:10116] [54024] (4 PDB entries)
  2. 2154605(Pro)cathepsin K [54028] (3 species)
    1. 2154606Species Human (Homo sapiens) [TaxId:9606] [54029] (51 PDB entries)
      Uniprot P43235 116-329 ! Uniprot P43235 115-329
    2. 2154662Species Rabbit (Oryctolagus cuniculus) [TaxId:9986] [142845] (1 PDB entry)
      Uniprot P43236 115-329
    3. 2285440Species Mus musculus [TaxId:10090] [328741] (1 PDB entry)
  3. 2154664(Pro)cathepsin L [54026] (1 species)
  4. 2154672(Pro)cathepsin S [82566] (1 species)
  5. 2154716(Pro)cathepsin V [64202] (1 species)
  6. 2154726(Pro)cathepsin X [54031] (1 species)
  7. 2154732Actinidin [54003] (1 species)
  8. 2154736Bleomycin hydrolase [54017] (2 species)
    DNA-binding protease that has more insertions in the papain-like fold
    1. 2154737Species Baker's yeast (Saccharomyces cerevisiae), Gal6 [TaxId:4932] [54018] (9 PDB entries)
    2. 2154747Species Human (Homo sapiens) [TaxId:9606] [54019] (2 PDB entries)
  9. 2154753Caricain (protease omega) [54007] (1 species)
  10. 2154760Cathepsin C (dipeptidyl peptidase I), catalytic domain [75330] (2 species)
    1. 2154761Species Human (Homo sapiens) [TaxId:9606] [75331] (1 PDB entry)
    2. 2154763Species Norway rat (Rattus norvegicus) [TaxId:10116] [82565] (1 PDB entry)
  11. 2154765Cathepsin F [89805] (1 species)
  12. 2154769Cathepsin H [81637] (1 species)
    also contains a disulfide-bound minicathepsin H chain
  13. 2154780Chymopapain [54009] (1 species)
  14. 2154783Cruzain [54020] (1 species)
  15. 2154829Ervatamin B [89803] (1 species)
  16. 2154832Ervatamin C [102717] (1 species)
  17. 2154836Falcipain 2 [142846] (1 species)
  18. 2154849Glycyl endopeptidase [54011] (1 species)
  19. 2154852Major mite fecal allergen der p 1 [142848] (1 species)
  20. 2154859Papain [54005] (1 species)
  21. 2154887Proline-specific cysteine protease [54013] (1 species)
  22. 2154893Staphopain SspB [102721] (1 species)
  23. 2154903Staphopain StpA [54033] (1 species)
  24. 2154906Streptococcal pyrogenic exotoxin B [54035] (1 species)
  25. 2154916Vignain (bean endopeptidase) [102719] (1 species)
  26. 2154920automated matches [190264] (11 species)
    not a true protein
    1. 2154921Species Actinidia arguta [TaxId:64478] [189532] (4 PDB entries)
    2. 2154926Species Carica candamarcensis [TaxId:35926] [189214] (1 PDB entry)
    3. 2154928Species Cow (Bos taurus) [TaxId:9913] [187053] (8 PDB entries)
    4. 2154937Species Ervatamia coronaria [311236] (1 PDB entry)
    5. 2154939Species Human (Homo sapiens) [TaxId:9606] [187102] (7 PDB entries)
    6. 2154952Species Jacaratia mexicana [TaxId:309130] [187452] (1 PDB entry)
    7. 2154957Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [188686] (2 PDB entries)
    8. 2154964Species Mouse (Mus musculus) [TaxId:10090] [229208] (7 PDB entries)
    9. 2154993Species Tabernaemontana divaricata [TaxId:52861] [187993] (3 PDB entries)
    10. 2155000Species Trypanosoma brucei [TaxId:31286] [188393] (2 PDB entries)
    11. 2272218Species Ficus carica [TaxId:3494] [315519] (1 PDB entry)

More info for Family d.3.1.1: Papain-like

Timeline for Family d.3.1.1: Papain-like: