SCOPe Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Three proposals to the NIH for continued funding have been unsuccessful. If our current NIH proposal is not funded, SCOPe will shut down permanently in Summer 2017 as Dr. Chandonia will need to seek a new position.

Lineage for Family c.94.1.1: Phosphate binding protein-like

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2144291Fold c.94: Periplasmic binding protein-like II [53849] (1 superfamily)
    consists of two similar intertwined domain with 3 layers (a/b/a) each: duplication
    mixed beta-sheet of 5 strands, order 21354; strand 5 is antiparallel to the rest
  4. 2144292Superfamily c.94.1: Periplasmic binding protein-like II [53850] (4 families) (S)
    Similar in architecture to the superfamily I but partly differs in topology
  5. 2144293Family c.94.1.1: Phosphate binding protein-like [53851] (45 protein domains)

Protein Domains:

  1. 2144294ABC transporter, periplasmic substrate-binding protein VCA0807 [117747] (1 species)
  2. 2144304Alginate-binding periplasmic protein AlgQ1 [142808] (1 species)
  3. 2144307Alginate-binding periplasmic protein AlgQ2 [69624] (1 species)
  4. 2144312ATP phosphoribosyltransferase (ATP-PRTase, HisG), catalytic domain [82559] (5 species)
    there is an additional C-terminal allosteric domain in some species
    1. 2144313Species Escherichia coli [TaxId:562] [102698] (2 PDB entries)
    2. 2144316Species Lactococcus lactis [TaxId:1358] [142804] (2 PDB entries)
      Uniprot Q02129 1-204
    3. 2144325Species Mycobacterium tuberculosis [TaxId:1773] [82560] (2 PDB entries)
    4. 2144328Species Thermotoga maritima [TaxId:2336] [102699] (3 PDB entries)
      Uniprot Q9X0D2
    5. 2144337Species Thermus thermophilus [TaxId:274] [142805] (1 PDB entry)
      Uniprot Q5SM15 1-206
  5. 2144339Bicarbonate transporter CmpA [310784] (1 species)
    member of Pfam PF13379
  6. 2144345Cofactor-binding fragment of LysR-type protein CysB [53886] (1 species)
  7. 2144348D-maltodextrin-binding protein, MBP [53862] (5 species)
    contains a few additional helices in the C-terminal extension; homologous to thiaminase I
    1. 2144349Species Alicyclobacillus acidocaldarius [TaxId:405212] [102690] (3 PDB entries)
    2. 2144355Species Escherichia coli K-12 [TaxId:83333] [159806] (11 PDB entries)
    3. 2144366Species Escherichia coli [TaxId:562] [53863] (65 PDB entries)
      Uniprot P02928
    4. 2144449Species Pyrococcus furiosus [TaxId:2261] [53864] (1 PDB entry)
    5. 2144451Species Thermococcus litoralis [TaxId:2265] [64191] (1 PDB entry)
      trehalose maltose-binding protein
  8. 2144453Dipeptide-binding protein [53870] (1 species)
    similar domain organization to oligopeptide-binding protein, OPPA
  9. 2144460Ferric-binding protein FbpA [53867] (7 species)
    1. 2144461Species Bordetella pertussis [TaxId:520] [117745] (1 PDB entry)
      Uniprot Q7VXW9 31-349
    2. 2144463Species Campylobacter jejuni [TaxId:197] [117744] (2 PDB entries)
      Uniprot Q9PIV4 17-334
    3. 2144467Species Haemophilus influenzae [TaxId:727] [53868] (12 PDB entries)
    4. 2144480Species Mannheimia haemolytica [TaxId:75985] [102691] (3 PDB entries)
      Uniprot Q9Z4N6
    5. 2144484Species Neisseria gonorrhoeae [TaxId:485] [53869] (5 PDB entries)
      Uniprot Q50964 23-331
    6. 2144522Species Serratia marcescens, SfuA [TaxId:615] [117743] (1 PDB entry)
      Uniprot P21408 32-338
    7. 2144524Species Yersinia enterocolitica, YfuA [TaxId:630] [117742] (1 PDB entry)
      Uniprot Q56925 28-338
  10. 2144526Glutamate receptor ligand binding core [53881] (5 species)
    1. 2144527Species Human (Homo sapiens) [TaxId:9606] [189807] (3 PDB entries)
    2. 2144535Species Norway rat (Rattus norvegicus), GluR2 [TaxId:10116] [53882] (134 PDB entries)
    3. 2144855Species Norway rat (Rattus norvegicus), GluR5 [TaxId:10116] [142802] (5 PDB entries)
      Uniprot P22756 429-546,667-799! Uniprot P22756 433-544,682-815
    4. 2144863Species Norway rat (Rattus norvegicus), GluR6 [TaxId:10116] [142801] (3 PDB entries)
      Uniprot P42260 421-544,668-804! Uniprot P42260 429-544,667-806
    5. 2144871Species Synechocystis sp., GluR0 [TaxId:1143] [64192] (3 PDB entries)
  11. 2144875Glutamine-binding protein [53879] (1 species)
  12. 2144880Glycine betaine-binding periplasmic protein ProX [102702] (1 species)
  13. 2144884Histidine-binding protein [53872] (2 species)
    1. 2144885Species Escherichia coli [TaxId:562] [53873] (1 PDB entry)
    2. Species Salmonella typhimurium [TaxId:90371] [53874] (1 PDB entry)
  14. 2144890Hydrogen peroxide-inducible genes LysR-type activator OxyR, regulatory domain [64193] (1 species)
  15. 2144895Hypothetical protein AF1704 [142810] (1 species)
    member of Pfam PF02642 (DUF191)
  16. 2144898Hypothetical protein DR0370 [159814] (1 species)
  17. 2144908Hypothetical protein SCo4506 [159810] (1 species)
  18. 2144914Hypothetical protein TTHA1568 [142806] (1 species)
    member of Pfam PF02642 (DUF191)
  19. 2144919Hypothetical protein YhfZ [159812] (1 species)
  20. 2144923Hypothetical protein YliB [102692] (1 species)
    similar domain organization to oligo- and dipeptide-binding protein
  21. 2144927Lysine-,arginine-,ornithine-binding (LAO) protein [53856] (1 species)
  22. 2144934LysR-type regulatory protein Cbl [142816] (1 species)
  23. 2144940LysR-type regulatory protein CbnR [89789] (1 species)
  24. 2144948LysR-type regulatory protein DntR [110748] (1 species)
  25. 2144954Molybdate-binding protein, ModA [53883] (3 species)
    1. 2144955Species Archaeoglobus fulgidus [TaxId:2234] [159807] (3 PDB entries)
      Uniprot O30142 32-342
    2. 2144960Species Azotobacter vinelandii [TaxId:354] [53885] (1 PDB entry)
    3. 2144962Species Escherichia coli [TaxId:562] [53884] (2 PDB entries)
  26. 2144965N-methyl-D-aspartate receptor subunit 1 [89787] (3 species)
    1. 2144966Species Norway rat (Rattus norvegicus) [TaxId:10116] [89788] (27 PDB entries)
    2. 2144984Species Norway rat (Rattus norvegicus), subtype 2A [TaxId:10116] [142803] (1 PDB entry)
      Uniprot Q00959 404-539,661-801
    3. 2271414Species Homo sapiens [TaxId:9606] [314718] (12 PDB entries)
  27. 2144986Nickel-binding periplasmic protein NikA [102694] (2 species)
    similar domain organization to oligo- and dipeptide-binding protein
    1. 2144987Species Brucella suis [TaxId:29461] [259856] (2 PDB entries)
    2. 2144991Species Escherichia coli [TaxId:562] [102695] (20 PDB entries)
  28. 2145030Nitrate-binding protein NtrA [310783] (1 species)
    member of Pfam PF13379
  29. 2145033Oligo-peptide binding protein (OPPA) [53852] (3 species)
    contains an additional alpha+beta domain inserted in the N-terminal domain
    1. 2145034Species Bacillus subtilis [TaxId:1423] [142799] (1 PDB entry)
      Uniprot P42061 40-543
    2. 2145036Species Salmonella typhimurium [TaxId:90371] [53853] (32 PDB entries)
    3. 2145070Species Thermotoga maritima [TaxId:2336] [142800] (3 PDB entries)
      Uniprot Q9X0V0 23-557
      TM1223
  30. 2145077Osmoprotection protein ProX [110750] (1 species)
    functionally related to the bacterial ProX
  31. 2145089Phosphate-binding protein [53860] (4 species)
    1. 2145090Species Escherichia coli [TaxId:562] [53861] (13 PDB entries)
    2. 2145105Species Mycobacterium tuberculosis [TaxId:1773] [110747] (1 PDB entry)
      Uniprot P15712
    3. 2145108Species Pseudomonas fluorescens [TaxId:216595] [189064] (1 PDB entry)
    4. 2145110Species Pseudomonas fluorescens [TaxId:294] [189065] (4 PDB entries)
  32. 2145115Porphobilinogen deaminase (hydroxymethylbilane synthase), N-terminal domain [53854] (1 species)
  33. 2145122Prephenate dehydratase [159808] (1 species)
  34. 2145128Probable LysR-type transcriptional regulator PA0477 [142812] (1 species)
  35. 2145134PstS-like phosphate-binding protein [159816] (1 species)
  36. 2145137Putative amino-acid transporter CjaA [142814] (1 species)
  37. 2145141Putative GluR0 ligand binding core [102696] (1 species)
  38. 2145145Putative lipoprotein (NlpA family) [102700] (2 species)
    aka PG110, TpN32
    1. 2145146Species Staphylococcus aureus [TaxId:1280] [102701] (1 PDB entry)
    2. 2145148Species Treponema pallidum [TaxId:160] [117746] (1 PDB entry)
      Uniprot O07950 28-267
  39. 2145150Putrescine receptor (PotF) [53877] (1 species)
  40. 2145156Sialic acid-binding protein SiaP [254345] (1 species)
    Pfam PF03480; TRAP transporter; homology to other Type II ESRs (Extracytoplasmic solute receptors) discussed in PubMed 16702222
  41. 2145167Spermidine/putrescine-binding protein PotD [53875] (1 species)
  42. 2145174Sulphate-binding protein [53858] (1 species)
  43. 2145177Thiaminase I [53865] (1 species)
    contains a few additional helices in the C-terminal extension; homologous to MBP
  44. 2145183TRAP dicarboxylate transporter [267666] (2 species)
    1. 2145184Species Polaromonas [TaxId:296591] [267752] (1 PDB entry)
    2. 2145186Species Rhodoferax ferrireducens [TaxId:338969] [267751] (2 PDB entries)
  45. 2145191automated matches [190140] (25 species)
    not a true protein
    1. 2145192Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:559292] [226716] (1 PDB entry)
    2. 2145194Species Bordetella pertussis [TaxId:257313] [187275] (2 PDB entries)
    3. 2145197Species Bradyrhizobium sp. [TaxId:288000] [267971] (1 PDB entry)
    4. 2145200Species Burkholderia cepacia [TaxId:292] [255595] (2 PDB entries)
    5. 2145205Species Burkholderia sp. [TaxId:233098] [190010] (5 PDB entries)
    6. 2145231Species Escherichia coli K-12 [TaxId:83333] [189211] (10 PDB entries)
    7. 2145259Species Escherichia coli [TaxId:536056] [255489] (2 PDB entries)
    8. 2145262Species Escherichia coli [TaxId:562] [189978] (9 PDB entries)
    9. 2145272Species Haemophilus influenzae [TaxId:727] [255670] (6 PDB entries)
    10. 2145279Species Human (Homo sapiens) [TaxId:9606] [189406] (4 PDB entries)
    11. 2145284Species Norway rat (Rattus norvegicus) [TaxId:10116] [189278] (33 PDB entries)
    12. 2145323Species Pasteurella multocida [TaxId:1169409] [257948] (1 PDB entry)
    13. 2145325Species Pseudomonas aeruginosa [TaxId:287] [195694] (2 PDB entries)
    14. 2145331Species Pseudomonas fluorescens [TaxId:216595] [311288] (1 PDB entry)
    15. 2145333Species Pseudomonas fluorescens [TaxId:294] [311289] (1 PDB entry)
    16. 2145335Species Salmonella enterica [TaxId:99287] [227690] (7 PDB entries)
    17. 2145345Species Sphingomonas sp. [TaxId:90322] [186866] (5 PDB entries)
    18. 2145352Species Thermotoga maritima [TaxId:243274] [259690] (3 PDB entries)
    19. 2145357Species Unidentified prokaryotic [TaxId:2725] [228734] (3 PDB entries)
    20. 2145363Species Yersinia pestis [TaxId:214092] [188272] (2 PDB entries)
    21. 2145367Species Yersinia pestis [TaxId:377628] [311500] (1 PDB entry)
    22. 2279468Species Escherichia coli [TaxId:83333] [322769] (1 PDB entry)
    23. 2280095Species Drosophila melanogaster [TaxId:7227] [323396] (2 PDB entries)
    24. 2287159Species Streptococcus pyogenes [TaxId:1314] [330460] (1 PDB entry)
    25. 2289191Species Xanthomonas axonopodis [TaxId:190486] [332492] (1 PDB entry)

More info for Family c.94.1.1: Phosphate binding protein-like

Timeline for Family c.94.1.1: Phosphate binding protein-like: