Lineage for Superfamily c.69.1: alpha/beta-Hydrolases

  1. Root: SCOPe 2.07
  2. 2413226Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2474355Fold c.69: alpha/beta-Hydrolases [53473] (1 superfamily)
    core: 3 layers, a/b/a; mixed beta-sheet of 8 strands, order 12435678, strand 2 is antiparallel to the rest
  4. 2474356Superfamily c.69.1: alpha/beta-Hydrolases [53474] (42 families) (S)
    many members have left-handed crossover connection between strand 8 and additional strand 9

Families:

  1. 2474357c.69.1.1: Acetylcholinesterase-like [53475] (6 proteins)
    automatically mapped to Pfam PF00135
  2. 2474832c.69.1.2: Carboxylesterase [53487] (7 proteins)
  3. 2474895c.69.1.3: Mycobacterial antigens [53491] (5 proteins)
    automatically mapped to Pfam PF00756
  4. 2474933c.69.1.4: Prolyl oligopeptidase, C-terminal domain [53496] (2 proteins)
    N-terminal domain is a 7-bladed beta-propeller
    automatically mapped to Pfam PF00326
  5. 2474966c.69.1.5: Serine carboxypeptidase-like [53499] (4 proteins)
    automatically mapped to Pfam PF00450
  6. 2474996c.69.1.6: Gastric lipase [53506] (1 protein)
  7. 2475004c.69.1.7: Proline iminopeptidase-like [53509] (4 proteins)
  8. 2475032c.69.1.8: Haloalkane dehalogenase [53513] (2 proteins)
  9. 2475115c.69.1.9: Dienelactone hydrolase [53518] (2 proteins)
    automatically mapped to Pfam PF01738
  10. 2475141c.69.1.10: Carbon-carbon bond hydrolase [53522] (3 proteins)
    closely related to the Proline iminopeptidase-like family
  11. 2475178c.69.1.11: Epoxide hydrolase [53525] (3 proteins)
  12. 2475308c.69.1.12: Haloperoxidase [53531] (8 proteins)
    automatically mapped to Pfam PF12697
    automatically mapped to Pfam PF00561
  13. 2475385c.69.1.13: Thioesterases [53542] (4 proteins)
  14. 2475402c.69.1.14: Carboxylesterase/thioesterase 1 [53547] (5 proteins)
  15. 2475433c.69.1.15: A novel bacterial esterase [53552] (2 proteins)
  16. 2475442c.69.1.16: Lipase [53555] (2 proteins)
  17. 2475467c.69.1.17: Fungal lipases [53558] (5 proteins)
  18. 2475619c.69.1.18: Bacterial lipase [53570] (4 proteins)
    lack the first two strands of the common fold
  19. 2475737c.69.1.19: Pancreatic lipase, N-terminal domain [53577] (2 proteins)
    automatically mapped to Pfam PF00151
  20. 2475764c.69.1.20: Hydroxynitrile lyase-like [53585] (3 proteins)
    automatically mapped to Pfam PF12697
  21. 2475847c.69.1.21: PepX catalytic domain-like [69581] (4 proteins)
  22. 2475910c.69.1.22: Thioesterase domain of polypeptide, polyketide and fatty acid synthases [69584] (4 proteins)
    Pfam PF00975
  23. 2475944c.69.1.23: Ccg1/TafII250-interacting factor B (Cib) [75285] (1 protein)
  24. 2475948c.69.1.24: DPP6 catalytic domain-like [82497] (2 proteins)
    N-terminal domain is a 8-bladed beta-propeller
    automatically mapped to Pfam PF00326
  25. 2476116c.69.1.25: Acetyl xylan esterase-like [82504] (3 proteins)
    Pfam PF05448; AXE1
  26. 2476256c.69.1.26: Biotin biosynthesis protein BioH [82509] (2 proteins)
    automatically mapped to Pfam PF12697
    automatically mapped to Pfam PF00561
  27. 2476266c.69.1.27: Hypothetical protein TT1662 [102616] (1 protein)
    automatically mapped to Pfam PF12697
  28. 2476275c.69.1.28: Aclacinomycin methylesterase RdmC [102620] (1 protein)
    automatically mapped to Pfam PF12697
  29. 2476280c.69.1.29: Carboxylesterase/lipase [102623] (1 protein)
    automatically mapped to Pfam PF12697
  30. 2476286c.69.1.30: Cutinase-like [52260] (3 proteins)
    minimal alpha/beta hydrolase lacking peripheral secondary structures; similar to a flavodoxin-like fold
    automatically mapped to Pfam PF01083
  31. 2476357c.69.1.31: YdeN-like [110699] (1 protein)
    Pfam PF06821; DUF1234; lack the first two strands of the common fold
  32. 2476361c.69.1.32: Putative serine hydrolase Ydr428c [110702] (1 protein)
  33. 2476366c.69.1.33: Acylamino-acid-releasing enzyme, C-terminal donain [117711] (1 protein)
    closely related to the prolyl peptidase and DPP6 domains ((53496) and 82497)
    automatically mapped to Pfam PF12697
  34. 2476393c.69.1.34: Hypothetical esterase YJL068C [117714] (2 proteins)
    part of Pfam PF00756
  35. 2476410c.69.1.35: Hypothetical protein VC1974 [117717] (1 protein)
    automatically mapped to Pfam PF00561
    automatically mapped to Pfam PF12697
  36. 2476414c.69.1.36: Atu1826-like [159742] (2 proteins)
  37. 2476422c.69.1.37: PHB depolymerase-like [159747] (1 protein)
  38. 2476427c.69.1.38: IroE-like [159750] (1 protein)
  39. 2476432c.69.1.39: TTHA1544-like [159753] (2 proteins)
    minimal hydrolase fold (one strand less than the cutinase-like family); there is neither catalytic triad, nor nucleopilic residue in the elbow motif
  40. 2476439c.69.1.40: O-acetyltransferase [159756] (2 proteins)
  41. 2476483c.69.1.41: 2,6-dihydropseudooxynicotine hydrolase-like [159762] (1 protein)
    Pfam PF06500; DUF1100
  42. 2476490c.69.1.0: automated matches [191404] (1 protein)
    not a true family

More info for Superfamily c.69.1: alpha/beta-Hydrolases

Timeline for Superfamily c.69.1: alpha/beta-Hydrolases: