SCOP 1.63: Superfamily c.31.1: DHS-like NAD/FAD-binding domain

Lineage for Superfamily c.31.1: DHS-like NAD/FAD-binding domain

1. Root: SCOP 1.63

2. Class c: Alpha and beta proteins (a/b) [51349] (117 folds)

3. Fold c.31: DHS-like NAD/FAD-binding domain [52466] (1 superfamily)
   3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456; Rossmann-like

4. Superfamily c.31.1: DHS-like NAD/FAD-binding domain [52467] (5 families)
   binds cofactor molecules in the opposite direction than classical Rossmann fold

Families:

1. c.31.1.1: Deoxyhypusine synthase, DHS [52468] (1 protein)

2. c.31.1.2: C-terminal domain of the electron transfer flavoprotein alpha subunit [52471] (1 protein)
   lacks strand 3; shares the FAD-binding mode with the pyruvate oxidase domain

3. c.31.1.3: Pyruvate oxidase and decarboxylase, middle domain [52475] (4 proteins)
   N-terminal domain is Pyr module, and C-terminal domain is PP module of thiamin diphosphate-binding fold

4. c.31.1.4: Transhydrogenase domain III (dIII) [52484] (1 protein)
   binds NADP, shares with the pyruvate oxidase FAD-binding domain a common ADP-binding mode

5. c.31.1.5: Sir2 family of transcriptional regulators [63984] (3 proteins)
   contains insertion of a rubredoxin-like zinc finger domain

More info for Superfamily c.31.1: DHS-like NAD/FAD-binding domain

Timeline for Superfamily c.31.1: DHS-like NAD/FAD-binding domain:

• Superfamily c.31.1: DHS-like NAD/FAD-binding domain first appeared (with stable ids) in SCOP 1.55
  
• Superfamily c.31.1: DHS-like NAD/FAD-binding domain appears in SCOP 1.61
  
• Superfamily c.31.1: DHS-like NAD/FAD-binding domain appears in SCOP 1.65
  
• Superfamily c.31.1: DHS-like NAD/FAD-binding domain appears in the current release, SCOPe 2.08