Welcome to the SCOPe website!

The SCOPe website provides integrated access to all data from the SCOP and ASTRAL databases, starting with version 1.55, the first version featuring stable identifiers. All releases from 1.55 to the current release can be found under the Stats & History tab.


  • The SCOP authors are Alexey G. Murzin, John-Marc Chandonia, Antonina Andreeva, Dave Howorth, Loredana Lo Conte, Bartlett G. Ailey, Steven E. Brenner, Tim J. P. Hubbard, and Cyrus Chothia.
  • The ASTRAL authors are John-Marc Chandonia, Naomi K. Fox, Degui Zhi, Gary Hon, Loredana Lo Conte, Nigel Walker, Patrice Koehl, Michael Levitt, and Steven E. Brenner.
  • References to cite are on this page.


Nearly all proteins have structural similarities with other proteins, and in some of these cases, share a common evolutionary origin. The Structural Classification of Proteins — extended (SCOPe) knowledgebase aims to provide an accurate, detailed, and comprehensive description of the structural and evolutionary relationships amongst all proteins of known structure, along with resources for analyzing the protein structures and their sequences. By providing a broad survey of protein folds and authoritative information about relatives of proteins, particularly those too ancient to be readily recognized from sequence, SCOPe is a framework for future research and classification. SCOPe undertakes to provide interfaces and data to support all users of protein structure and evolutionary relationships, for research, education, and policy, at scales ranging from interactive exploration of relationships of proteins of interest, including nuances of their individual structures and variations, to comprehensive studies and methods that draw on the entirety of the protein universe. The SCOPe resource aims to be Findable/Accessible/Interoperable/Reusable (FAIR) and also equitable for all.


All releases of SCOP version 1 and ASTRAL from 1.55 through 1.75 are available through this website.


Since 2004-07-01, all SCOP data have been freely available to all users, according to the license agreement. All ASTRAL data are also freely available to all users.


This work was supported by the National Institutes of Health (R01-GM073109) through the U.S. Department of Energy under Contract No. DE-AC02-05CH11231.