Lineage for Family c.26.1.1: Class I aminoacyl-tRNA synthetases (RS), catalytic domain

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2105373Fold c.26: Adenine nucleotide alpha hydrolase-like [52373] (3 superfamilies)
    core: 3 layers, a/b/a ; parallel beta-sheet of 5 strands, order 32145
  4. 2105374Superfamily c.26.1: Nucleotidylyl transferase [52374] (6 families) (S)
  5. 2105375Family c.26.1.1: Class I aminoacyl-tRNA synthetases (RS), catalytic domain [52375] (13 protein domains)
    contains a conserved all-alpha subdomain at the C-terminal extension

Protein Domains:

  1. 2105376Arginyl-tRNA synthetase (ArgRS) [52392] (2 species)
    1. 2105377Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [52393] (3 PDB entries)
    2. 2105381Species Thermus thermophilus [TaxId:274] [69454] (1 PDB entry)
  2. 2105383Class I lysyl-tRNA synthetase [75159] (1 species)
    similar domain organization to GluRS
  3. 2105387Cysteinyl-tRNA synthetase (CysRS) [75161] (1 species)
  4. 2105394Glutaminyl-tRNA synthetase (GlnRS) [52380] (2 species)
    1. 2105395Species Escherichia coli K-12 [TaxId:83333] [159495] (1 PDB entry)
    2. 2105397Species Escherichia coli [TaxId:562] [52381] (17 PDB entries)
  5. 2105415Glutamyl-Q tRNA-Asp synthetase YadB [102257] (1 species)
    truncated GluRS and GlnRS homologue lacking the anticodon-binding domain; glutamylates the modified base queuosine (Q) of tRNA-Asp
  6. 2105420Glutamyl-tRNA synthetase (GluRS) [52382] (1 species)
    Catalytic domain is very similar to that of GlnRS
  7. 2105440Isoleucyl-tRNA synthetase (IleRS) [52387] (2 species)
    1. 2105441Species Staphylococcus aureus [TaxId:1280] [52389] (3 PDB entries)
    2. 2105445Species Thermus thermophilus [TaxId:274] [52388] (3 PDB entries)
  8. 2105449Leucyl-tRNA synthetase (LeuRS) [82356] (1 species)
    • 2105450Species Thermus thermophilus [TaxId:274] [82357] (3 PDB entries)
      contains a non-conserved insertion (residues 581-633) that forms a separate subdomain; possible rudiment Zn finger
  9. 2105454Methionyl-tRNA synthetase (MetRS) [52384] (3 species)
    1. 2105455Species Escherichia coli [TaxId:562] [52386] (9 PDB entries)
    2. 2105465Species Pyrococcus abyssi [TaxId:29292] [110490] (1 PDB entry)
      Uniprot Q9V011 1-606 # C-domain 616-722 is solved separately: 1MKH
    3. Species Thermus thermophilus [TaxId:274] [52385] (1 PDB entry)
  10. 2105469Tryptophanyl-tRNA synthetase (TrpRS) [52378] (5 species)
    overall structure is similar to TyrRS
    1. 2105470Species Bacillus stearothermophilus [TaxId:1422] [52379] (12 PDB entries)
    2. 2105520Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [255912] (4 PDB entries)
    3. 2105534Species Human (Homo sapiens) [TaxId:9606] [102256] (11 PDB entries)
      Uniprot P23381 94-471
    4. 2105553Species Thermotoga maritima [TaxId:2336] [187734] (1 PDB entry)
    5. 2105555Species Thermus thermophilus HB8 [TaxId:300852] [188378] (1 PDB entry)
  11. 2105558Tyrosyl-tRNA synthetase (TyrRS) [52376] (6 species)
    1. 2105559Species Bacillus stearothermophilus, nca 1503 [TaxId:1422] [52377] (7 PDB entries)
    2. 2105568Species Escherichia coli [TaxId:316407] [188087] (3 PDB entries)
    3. 2105572Species Human (Homo sapiens) [TaxId:9606] [82355] (6 PDB entries)
    4. 2105577Species Methanococcus jannaschii [TaxId:2190] [89611] (9 PDB entries)
    5. 2105590Species Staphylococcus aureus [TaxId:1280] [69453] (4 PDB entries)
    6. 2105595Species Thermus thermophilus [TaxId:274] [82354] (2 PDB entries)
  12. 2105599Valyl-tRNA synthetase (ValRS) [52390] (1 species)
  13. 2105607automated matches [190581] (9 species)
    not a true protein
    1. 2105608Species Archaeoglobus fulgidus [TaxId:2234] [187585] (1 PDB entry)
    2. 2105611Species Escherichia coli [TaxId:562] [188048] (3 PDB entries)
    3. 2105617Species Methanocaldococcus jannaschii [TaxId:2190] [188187] (8 PDB entries)
    4. 2105626Species Methanocaldococcus jannaschii [TaxId:243232] [193079] (10 PDB entries)
    5. 2105637Species Thermus thermophilus HB8 [TaxId:300852] [233866] (1 PDB entry)
    6. 2105639Species Thermus thermophilus [TaxId:274] [254946] (3 PDB entries)
    7. 2105643Species Vibrio cholerae [TaxId:243277] [196171] (1 PDB entry)
    8. 2105645Species Yersinia pestis [TaxId:214092] [189402] (1 PDB entry)
    9. 2288952Species Escherichia coli [TaxId:155864] [332253] (1 PDB entry)

More info for Family c.26.1.1: Class I aminoacyl-tRNA synthetases (RS), catalytic domain

Timeline for Family c.26.1.1: Class I aminoacyl-tRNA synthetases (RS), catalytic domain: