SCOPe Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Three proposals to the NIH for continued funding have been unsuccessful. If our current NIH proposal is not funded, SCOPe will shut down permanently in Summer 2017 as Dr. Chandonia will need to seek a new position.

Lineage for Family c.1.11.2: D-glucarate dehydratase-like

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2078560Fold c.1: TIM beta/alpha-barrel [51350] (33 superfamilies)
    contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
    the first seven superfamilies have similar phosphate-binding sites
  4. 2086988Superfamily c.1.11: Enolase C-terminal domain-like [51604] (3 families) (S)
    binds metal ion (magnesium or manganese) in conserved site inside barrel
    N-terminal alpha+beta domain is common to this superfamily
  5. 2087095Family c.1.11.2: D-glucarate dehydratase-like [51609] (15 protein domains)

Protein Domains:

  1. 2087096beta-Methylaspartase [69400] (2 species)
    1. 2087097Species Citrobacter amalonaticus [TaxId:35703] [69402] (2 PDB entries)
    2. 2087102Species Clostridium tetanomorphum [TaxId:1553] [69401] (2 PDB entries)
  2. 2087107Chlormuconate cycloisomerase [51619] (2 species)
    1. 2087108Species Alcaligenes eutrophus [TaxId:106590] [51620] (1 PDB entry)
    2. 2087110Species Pseudomonas sp. p51 [TaxId:65067] [102096] (1 PDB entry)
  3. 2087112D-glucarate dehydratase [51610] (2 species)
    1. 2087113Species Escherichia coli [TaxId:562] [51612] (7 PDB entries)
    2. 2087138Species Pseudomonas putida [TaxId:303] [51611] (1 PDB entry)
  4. 2087140D-mannonate dehydratase [267664] (1 species)
  5. 2087146Hypothetical protein Atu3453 [102097] (1 species)
  6. 2087149Hypothetical protein Bll6730 [117384] (1 species)
  7. 2087153Hypothetical protein YitF [141844] (1 species)
  8. 2087165L-Ala-D/L-Glu epimerase [69397] (2 species)
    1. 2087166Species Bacillus subtilis [TaxId:1423] [69399] (2 PDB entries)
      Uniprot O34508
    2. 2087179Species Escherichia coli [TaxId:562] [69398] (1 PDB entry)
  9. 2087181Mandelate racemase [51617] (3 species)
    1. 2087182Species Clostridium beijerinckii [TaxId:290402] [267745] (2 PDB entries)
    2. 2087187Species Dickeya dadantii [TaxId:579405] [267743] (1 PDB entry)
    3. 2087196Species Pseudomonas putida [TaxId:303] [51618] (6 PDB entries)
  10. 2087203Muconate-lactonizing enzyme [51615] (1 species)
  11. 2087216N-acylamino acid racemase [110372] (4 species)
    1. 2087217Species Amycolatopsis sp. [TaxId:37632] [110373] (4 PDB entries)
      Uniprot Q44244 # similar activity to a remotely related O-succinylbenzoate synthase from E. coli
    2. 2087234Species Deinococcus radiodurans [TaxId:1299] [110374] (5 PDB entries)
      Uniprot Q9RYA6
    3. 2087255Species Enterococcus faecalis [TaxId:1351] [117382] (1 PDB entry)
      Uniprot Q838J7; EF0450; protein assignment by sequence similarity
    4. 2087258Species Listeria innocua [TaxId:1642] [117383] (1 PDB entry)
      Uniprot Q927X3; Lin2664; protein assignment by sequence similarity
  12. 2087261O-succinylbenzoate synthase [51613] (1 species)
  13. 2087270Putative dehydratase protein STM2273 [141846] (2 species)
    1. 2087271Species Salmonella enterica [TaxId:90371] [226347] (1 PDB entry)
    2. 2087280Species Salmonella typhimurium [TaxId:90371] [141847] (1 PDB entry)
      Uniprot Q8ZNH1 123-400
  14. 2087283RTS beta protein [117386] (1 species)
  15. 2087289automated matches [226997] (13 species)
    not a true protein
    1. 2087290Species Acidaminococcus sp. [TaxId:563191] [234735] (1 PDB entry)
    2. 2087293Species Actinobacillus succinogenes [TaxId:339671] [226437] (1 PDB entry)
    3. 2087298Species Agrobacterium tumefaciens [TaxId:176299] [226506] (6 PDB entries)
    4. Species Bradyrhizobium japonicum [TaxId:375] [255123] (2 PDB entries)
    5. 2087331Species Cupriavidus necator [TaxId:106590] [311123] (1 PDB entry)
    6. 2087334Species Escherichia coli [TaxId:444449] [233282] (2 PDB entries)
    7. 2087340Species Pantoea ananatis [TaxId:706191] [267884] (1 PDB entry)
    8. 2087343Species Pectobacterium carotovorum [TaxId:561230] [267927] (1 PDB entry)
    9. 2087348Species Pseudomonas putida [TaxId:303] [228631] (6 PDB entries)
    10. 2087362Species Salmonella enterica [TaxId:550537] [267890] (3 PDB entries)
    11. 2087377Species Salmonella typhimurium [TaxId:602] [225624] (1 PDB entry)
    12. 2087379Species Vibrionales bacterium [TaxId:391574] [267878] (2 PDB entries)
    13. 2282906Species Amycolatopsis sp. [TaxId:37632] [326207] (5 PDB entries)

More info for Family c.1.11.2: D-glucarate dehydratase-like

Timeline for Family c.1.11.2: D-glucarate dehydratase-like: