SCOPe Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Three proposals to the NIH for continued funding have been unsuccessful. If our current NIH proposal is not funded, SCOPe will shut down permanently in Summer 2017 as Dr. Chandonia will need to seek a new position.

Lineage for Family c.1.8.1: Amylase, catalytic domain

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2078560Fold c.1: TIM beta/alpha-barrel [51350] (33 superfamilies)
    contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
    the first seven superfamilies have similar phosphate-binding sites
  4. 2081496Superfamily c.1.8: (Trans)glycosidases [51445] (15 families) (S)
  5. 2081497Family c.1.8.1: Amylase, catalytic domain [51446] (26 protein domains)
    members of the family may contain various insert subdomains
    in alpha-amylases and closer relatives this domain is usually followed by a common all-beta domain

Protein Domains:

  1. 20814981,4-alpha-glucan branching enzyme, central domain [82244] (1 species)
  2. 20815044-alpha-glucanotransferase [75062] (1 species)
  3. 2081510A4 beta-galactosidase [82246] (1 species)
    the catalytic domain is very similar to that of the bacterial beta-amylase; but contains a typical alpha-amylase extra domain
  4. 2081514Amylomaltase MalQ [51478] (3 species)
    4-alpha-glucanotransferase; single-domain amylase with several insertions in the common fold
    1. 2081515Species Aquifex aeolicus [TaxId:63363] [141770] (1 PDB entry)
      Uniprot O66937 1-485
    2. 2081518Species Potato (Solanum tuberosum) [TaxId:4113] [141771] (1 PDB entry)
      Uniprot Q06801 54-576
    3. 2081520Species Thermus aquaticus [TaxId:271] [51479] (4 PDB entries)
      synonym: Thermus thermophilus
  5. 2081525Amylosucrase [69384] (1 species)
  6. 2081537Animal alpha-amylase [51458] (3 species)
    contains Ca2+-binding subdomain, residues 100-170
    1. 2081538Species Human (Homo sapiens) [TaxId:9606] [51460] (52 PDB entries)
      Uniprot P04746 16-511 ! SQ 04746
    2. 2081588Species Pig (Sus scrofa) [TaxId:9823] [51459] (13 PDB entries)
    3. 2081608Species Yellow mealworm (Tenebrio molitor), larva [TaxId:7067] [51461] (4 PDB entries)
  7. 2081613Bacterial alpha-amylase [51447] (10 species)
    1. Species Bacillus halmapalus [TaxId:79882] [141768] (1 PDB entry)
      Uniprot P19571 38-431
    2. 2081616Species Bacillus licheniformis [TaxId:1402] [51448] (4 PDB entries)
    3. 2081621Species Bacillus sp. 707 [TaxId:1416] [117366] (4 PDB entries)
      Uniprot P19571 38-518
    4. 2081626Species Bacillus sp., ksm-k38 [TaxId:1409] [89463] (6 PDB entries)
    5. 2081633Species Bacillus stearothermophilus [TaxId:1422] [51451] (1 PDB entry)
    6. 2081635Species Bacillus subtilis [TaxId:1423] [51450] (2 PDB entries)
      Uniprot P00691
    7. 2081638Species Chimera (Bacillus amyloliquefaciens) and (Bacillus licheniformis) [TaxId:1390] [63903] (4 PDB entries)
      the N-terminal 300 residues are from B. amyloliquefaciens
    8. 2081643Species Halothermothrix orenii [TaxId:31909] [141767] (1 PDB entry)
      Uniprot Q8GPL8 28-436
    9. 2081645Species Pseudoalteromonas haloplanktis [TaxId:228] [51449] (9 PDB entries)
    10. 2081655Species Pyrococcus woesei [TaxId:2262] [89464] (3 PDB entries)
  8. 2081659Bacterial beta-amylase [51485] (1 species)
    protein contains additional starch-binding domain
  9. 2081690beta-Amylase [51481] (3 species)
    Common fold covers whole protein structure
    1. 2081691Species Barley (Hordeum vulgare) [TaxId:4513] [51483] (1 PDB entry)
    2. 2081693Species Soybean (Glycine max) [TaxId:3847] [51482] (18 PDB entries)
      Uniprot P10538
    3. 2081718Species Sweet potato (Ipomoea batatas) [TaxId:4120] [51484] (1 PDB entry)
  10. 2081720Cyclodextrin glycosyltransferase [51452] (5 species)
    contains two more all-beta domains, one is Immunoglobulin-like and the other is trasthyretin-like
    1. 2081721Species Bacillus circulans, different strains [TaxId:1397] [51453] (36 PDB entries)
    2. 2081762Species Bacillus sp. 1011, alkaliphilic [TaxId:1410] [51456] (8 PDB entries)
      Uniprot P05618
    3. 2081779Species Bacillus stearothermophilus [TaxId:1422] [51454] (1 PDB entry)
    4. 2081781Species Bacillus stearothermophilus, maltogenic alpha-amylase [TaxId:1422] [51455] (2 PDB entries)
    5. 2081784Species Thermoanaerobacterium thermosulfurigenes, EM1 [TaxId:33950] [51457] (4 PDB entries)
  11. 2081789Cyclomaltodextrinase, central domain [102058] (1 species)
    protein shares similar domain organization with maltogenic amylases but differs in the spatial arrangement of its domains
  12. 2081793Fungal alpha-amylases [51462] (2 species)
    1. 2081794Species Aspergillus niger, acid amylase [TaxId:5061] [51463] (1 PDB entry)
    2. 2081796Species Aspergillus oryzae, Taka-amylase [TaxId:5062] [51464] (8 PDB entries)
  13. 2081808G4-amylase (1,4-alpha-D-glucan maltotetrahydrolase) [51472] (1 species)
  14. 2081819Glycosyltrehalose trehalohydrolase, central domain [51468] (2 species)
    contains an additional N-terminal domain
    1. 2081820Species Deinococcus radiodurans [TaxId:1299] [141769] (9 PDB entries)
      Uniprot Q9RX51 111-528
    2. 2081830Species Sulfolobus solfataricus, km1 [TaxId:2287] [51469] (8 PDB entries)
  15. 2081839Isoamylase, central domain [51470] (1 species)
  16. 2081842Isomaltulose synthase PalI [89466] (2 species)
    1. 2081843Species Erwinia rhapontici [TaxId:55212] [254869] (5 PDB entries)
    2. 2081849Species Klebsiella sp., lx3 [TaxId:576] [89467] (1 PDB entry)
  17. 2081851Maltogenic amylase, central domain [51465] (4 species)
    contains an additional N-terminal domain
    1. 2081852Species Bacillus sp., cyclomaltodextrinase [TaxId:1409] [75060] (1 PDB entry)
    2. 2081855Species Thermoactinomyces vulgaris, TVAI [TaxId:2026] [75061] (8 PDB entries)
    3. 2081865Species Thermoactinomyces vulgaris, TVAII [TaxId:2026] [51467] (12 PDB entries)
    4. 2081890Species Thermus sp. [TaxId:275] [51466] (2 PDB entries)
  18. 2081895Maltooligosyl trehalose synthase [82242] (1 species)
    elaborated with several large insertions in the common fold
  19. 2081898Maltosyltransferase [63904] (1 species)
    similar to bacterial alpha-amylase; contains larger insertion domain
  20. 2081902Melibiase [75064] (4 species)
    1. 2081903Species Chicken (Gallus gallus) [TaxId:9031] [75065] (2 PDB entries)
      alpha-N-acetylgalactosaminidase
    2. 2081906Species Human (Homo sapiens) [TaxId:9606] [102062] (17 PDB entries)
      alpha-galactosidase A
    3. 2081941Species Rice (Oryza sativa) [TaxId:4530] [89468] (1 PDB entry)
      alpha-galactosidase
    4. 2081943Species Trichoderma reesei [TaxId:51453] [110349] (2 PDB entries)
      Alpha-galactosidase agl1
      Uniprot Q92456
  21. 2081946Neopullulanase, central domain [82240] (1 species)
    homologous to Maltogenic amylase
  22. 2081956Oligo-1,6, glucosidase [51476] (1 species)
  23. 2081959Plant alpha-amylase [51474] (2 species)
    1. 2081960Species Barley (Hordeum vulgare), AMY1 isozyme [TaxId:4513] [89465] (7 PDB entries)
    2. 2081970Species Barley (Hordeum vulgare), seeds, AMY2 isozyme [TaxId:4513] [51475] (3 PDB entries)
  24. 2081975Pullulanase PulA [159381] (1 species)
  25. 2081983Sucrose phosphorylase [102060] (1 species)
    sequence and close structural relationship to amylosucrase; variations in the C-terminal domain fold
  26. 2081989automated matches [190099] (25 species)
    not a true protein
    1. Species Bacillus cereus [TaxId:1396] [254917] (3 PDB entries)
    2. 2081994Species Bacillus halmapalus [TaxId:79882] [255187] (2 PDB entries)
    3. 2081997Species Bacillus sp. [225222] (1 PDB entry)
    4. 2081999Species Bacillus sp. [TaxId:535911] [225472] (1 PDB entry)
    5. 2082001Species Bacillus subtilis [TaxId:224308] [228099] (4 PDB entries)
    6. 2082007Species Barley (Hordeum vulgare) [TaxId:4513] [255684] (8 PDB entries)
    7. 2082016Species Bifidobacterium adolescentis [TaxId:1680] [255183] (1 PDB entry)
    8. 2082019Species Escherichia coli [TaxId:331111] [311496] (3 PDB entries)
    9. 2082032Species Escherichia coli [TaxId:562] [270950] (4 PDB entries)
    10. 2082049Species Flavobacterium sp. [TaxId:197856] [255816] (5 PDB entries)
    11. 2082060Species Geobacillus stearothermophilus [TaxId:1422] [311444] (1 PDB entry)
    12. 2082062Species Human (Homo sapiens) [TaxId:9606] [225770] (13 PDB entries)
    13. 2082084Species Listeria monocytogenes [TaxId:169963] [277525] (1 PDB entry)
    14. 2082088Species Neisseria polysaccharea [TaxId:489] [226280] (5 PDB entries)
    15. 2082094Species Oryzias latipes [TaxId:8090] [226401] (1 PDB entry)
    16. 2082096Species Pig (Sus scrofa) [TaxId:9823] [225875] (3 PDB entries)
    17. 2082100Species Protaminobacter rubrum [TaxId:126825] [225680] (2 PDB entries)
    18. 2082103Species Pseudomonas mesoacidophila [TaxId:265293] [224875] (9 PDB entries)
    19. 2082124Species Pyrococcus woesei [TaxId:2262] [226292] (1 PDB entry)
    20. 2082126Species Soybean (Glycine max) [TaxId:3847] [186821] (2 PDB entries)
    21. 2082129Species Thale cress (Arabidopsis thaliana) [TaxId:3702] [278910] (6 PDB entries)
    22. 2082142Species Thermoactinomyces vulgaris [TaxId:2026] [254920] (6 PDB entries)
    23. 2082154Species Thermus brockianus [TaxId:56956] [189542] (1 PDB entry)
    24. 2082156Species Thermus thermophilus [TaxId:274] [188525] (3 PDB entries)
    25. 2285620Species Thermus aquaticus [TaxId:271] [328921] (1 PDB entry)

More info for Family c.1.8.1: Amylase, catalytic domain

Timeline for Family c.1.8.1: Amylase, catalytic domain: