SCOP 1.73: Protein: Cyclophilin (eukaryotic)

Lineage for Protein: Cyclophilin (eukaryotic)

Root: SCOP 1.73
Class b: All beta proteins [48724] (165 folds)
Fold b.62: Cyclophilin-like [50890] (1 superfamily)
barrel, closed; n=8, S=10; complex topology
Superfamily b.62.1: Cyclophilin-like [50891] (3 families)
Family b.62.1.1: Cyclophilin (peptidylprolyl isomerase) [50892] (12 proteins)
Protein Cyclophilin (eukaryotic) [50893] (13 species)

Species:

Aspergillus fumigatus [TaxId:5085] [141499] (1 PDB entry)
- Domains for 2c3b:
  1. Domain d2c3ba1: 2c3b A:1-171 [129723]
    complexed with so4
  2. Domain d2c3bb1: 2c3b B:1-171 [129724]
    automatically matched to 2C3B A:1-171
    complexed with so4
Baker's yeast (Saccharomyces cerevisiae), variant A [TaxId:4932] [101878] (2 PDB entries)
1. Domains for 1ist:
  1. Domain d1ista_: 1ist A: [90692]
  2. Domain d1istb_: 1ist B: [90693]
2. Domain for 1vdn:
  - Domain d1vdna1: 1vdn A:2-162 [120006]
    automatically matched to d1ista_
    complexed with ace, mcm
Caenorhabditis elegans, isoform 3 [TaxId:6239] [50899] (3 PDB entries)
1. Domain for 1dyw:
  - Domain d1dywa_: 1dyw A: [27505]
2. Domain for 1e3b:
  - Domain d1e3ba_: 1e3b A: [27506]
    complexed with 3ep, au
3. Domain for 1e8k:
  - Domain d1e8ka_: 1e8k A: [64797]
    complexed with ala, pro
Caenorhabditis elegans, isoform 5 [TaxId:6239] [82161] (1 PDB entry)
- Domain for 1h0p:
  - Domain d1h0pa_: 1h0p A: [76450]
    complexed with dtt; mutant
Human (Homo sapiens), U4/U6 snRNP-specific cyclophilin snucyp-20 [TaxId:9606] [50896] (2 PDB entries)
1. Domain for 1mzw:
  - Domain d1mzwa_: 1mzw A: [91503]
    complexed with a 30-residue peptide from U4/U6 snRNP 60kda protein, chain B
2. Domain for 1qoi:
  - Domain d1qoia_: 1qoi A: [27490]

Human (Homo sapiens), variant A [TaxId:9606] [50894] (48 PDB entries)

Domains for 1ak4:
1. Domain d1ak4a_: 1ak4 A: [27472]
  Other proteins in same PDB: d1ak4c_, d1ak4d_
2. Domain d1ak4b_: 1ak4 B: [27473]
  Other proteins in same PDB: d1ak4c_, d1ak4d_
  mutant
Domain for 1awq:
- Domain d1awqa_: 1awq A: [27461]
Domains for 1awr:
1. Domain d1awra_: 1awr A: [27464]
2. Domain d1awrb_: 1awr B: [27465]
3. Domain d1awrc_: 1awr C: [27466]
4. Domain d1awrd_: 1awr D: [27467]
5. Domain d1awre_: 1awr E: [27468]
6. Domain d1awrf_: 1awr F: [27469]
Domain for 1aws:
- Domain d1awsa_: 1aws A: [27431]
  mutant
Domains for 1awt:
1. Domain d1awta_: 1awt A: [27481]
2. Domain d1awtb_: 1awt B: [27482]
3. Domain d1awtc_: 1awt C: [27483]
4. Domain d1awtd_: 1awt D: [27484]
5. Domain d1awte_: 1awt E: [27485]
6. Domain d1awtf_: 1awt F: [27486]
  mutant
Domain for 1awu:
- Domain d1awua_: 1awu A: [27474]
Domains for 1awv:
1. Domain d1awva_: 1awv A: [27475]
2. Domain d1awvb_: 1awv B: [27476]
3. Domain d1awvc_: 1awv C: [27477]
4. Domain d1awvd_: 1awv D: [27478]
5. Domain d1awve_: 1awv E: [27479]
6. Domain d1awvf_: 1awv F: [27480]
Domain for 1bck:
- Domain d1bcka_: 1bck A: [27427]
Domain for 1cwa:
- Domain d1cwaa_: 1cwa A: [27434]
  complexed with aba
Domain for 1cwb:
- Domain d1cwba_: 1cwb A: [27459]
  complexed with aba, dmt
Domain for 1cwc:
- Domain d1cwca_: 1cwc A: [27428]
  complexed with aba, mnl
Domain for 1cwf:
- Domain d1cwfa_: 1cwf A: [27429]
Domain for 1cwh:
- Domain d1cwha_: 1cwh A: [27430]
  complexed with aba, dse
Domain for 1cwi:
- Domain d1cwia_: 1cwi A: [27458]
Domain for 1cwj:
- Domain d1cwja_: 1cwj A: [27425]
  complexed with mnv, tbm
Domain for 1cwk:
- Domain d1cwka_: 1cwk A: [27422]
  complexed with tmd
Domain for 1cwl:
- Domain d1cwla_: 1cwl A: [27423]
  complexed with aba, mgy, mhl
Domain for 1cwm:
- Domain d1cwma_: 1cwm A: [27433]
  complexed with aba, iml, tmb
Domain for 1cwo:
- Domain d1cwoa_: 1cwo A: [27445]
  complexed with vad
Domain for 1fgl:
- Domain d1fgla_: 1fgl A: [27426]

Domains for 1m63:

Domain d1m63c_: 1m63 C: [78679]
Other proteins in same PDB: d1m63a_, d1m63b_, d1m63e_, d1m63f_

Domain d1m63g_: 1m63 G: [78682]
Other proteins in same PDB: d1m63a_, d1m63b_, d1m63e_, d1m63f_
complexed with calcineurin and cyclosporin (chain D and H)
complexed with aba, bmt, ca, dal, fe, mle, mva, sar, zn

Domains for 1m9c:
1. Domain d1m9ca_: 1m9c A: [84886]
  Other proteins in same PDB: d1m9cc_, d1m9cd_
2. Domain d1m9cb_: 1m9c B: [84887]
  Other proteins in same PDB: d1m9cc_, d1m9cd_
Domains for 1m9d:
1. Domain d1m9da_: 1m9d A: [84890]
  Other proteins in same PDB: d1m9dc_, d1m9dd_
2. Domain d1m9db_: 1m9d B: [84891]
  Other proteins in same PDB: d1m9dc_, d1m9dd_
  mutant
Domains for 1m9e:
1. Domain d1m9ea_: 1m9e A: [84894]
  Other proteins in same PDB: d1m9ec_, d1m9ed_
2. Domain d1m9eb_: 1m9e B: [84895]
  Other proteins in same PDB: d1m9ec_, d1m9ed_
  mutant
Domains for 1m9f:
1. Domain d1m9fa_: 1m9f A: [84898]
  Other proteins in same PDB: d1m9fc_, d1m9fd_
2. Domain d1m9fb_: 1m9f B: [84899]
  Other proteins in same PDB: d1m9fc_, d1m9fd_
  mutant
Domains for 1m9x:
1. Domain d1m9xa_: 1m9x A: [84905]
  Other proteins in same PDB: d1m9xc_, d1m9xd_, d1m9xg_, d1m9xh_
2. Domain d1m9xb_: 1m9x B: [84906]
  Other proteins in same PDB: d1m9xc_, d1m9xd_, d1m9xg_, d1m9xh_
3. Domain d1m9xe_: 1m9x E: [84909]
  Other proteins in same PDB: d1m9xc_, d1m9xd_, d1m9xg_, d1m9xh_
4. Domain d1m9xf_: 1m9x F: [84910]
  Other proteins in same PDB: d1m9xc_, d1m9xd_, d1m9xg_, d1m9xh_
  mutant
Domains for 1m9y:
1. Domain d1m9ya_: 1m9y A: [84913]
  Other proteins in same PDB: d1m9yc_, d1m9yd_, d1m9yg_, d1m9yh_
2. Domain d1m9yb_: 1m9y B: [84914]
  Other proteins in same PDB: d1m9yc_, d1m9yd_, d1m9yg_, d1m9yh_
3. Domain d1m9ye_: 1m9y E: [84917]
  Other proteins in same PDB: d1m9yc_, d1m9yd_, d1m9yg_, d1m9yh_
4. Domain d1m9yf_: 1m9y F: [84918]
  Other proteins in same PDB: d1m9yc_, d1m9yd_, d1m9yg_, d1m9yh_
  mutant
Domain for 1mf8:
- Domain d1mf8c_: 1mf8 C: [79042]
  Other proteins in same PDB: d1mf8a_, d1mf8b_
  complexed with aba, bmt, ca, dal, mle, mva, po4, sar
Domain for 1mik:
- Domain d1mika_: 1mik A: [27424]
  complexed with dhn
Domains for 1nmk:
1. Domain d1nmka_: 1nmk A: [85875]
2. Domain d1nmkb_: 1nmk B: [85876]
  complexed with sfm
Domain for 1oca:
- Domain d1ocaa_: 1oca A: [27487]
Domains for 1rmh:
1. Domain d1rmha_: 1rmh A: [27470]
2. Domain d1rmhb_: 1rmh B: [27471]
  complexed with nit, sin
Domain for 1vbs:
- Domain d1vbsa_: 1vbs A: [27456]
  complexed with nit
Domains for 1vbt:
1. Domain d1vbta_: 1vbt A: [27462]
2. Domain d1vbtb_: 1vbt B: [27463]
  complexed with alt, nit
Domain for 1w8l:
- Domain d1w8la_: 1w8l A: [114369]
  complexed with 1p3
Domain for 1w8m:
- Domain d1w8ma_: 1w8m A: [114370]
  complexed with e1p
Domain for 1w8v:
- Domain d1w8va_: 1w8v A: [114377]
Domains for 1ynd:
1. Domain d1ynda1: 1ynd A:2-165 [123721]
  automatically matched to d1ak4a_
  complexed with sfa
2. Domain d1yndb1: 1ynd B:2-165 [123722]
  automatically matched to d1ak4a_
  complexed with sfa
Domains for 1zkf:
1. Domain d1zkfa1: 1zkf A:2-165 [125192]
  automatically matched to d1ak4a_
  complexed with nit, sin
2. Domain d1zkfb1: 1zkf B:2-165 [125193]
  automatically matched to d1ak4a_
  complexed with nit, sin
Domain for 2alf:
- Domain d2alfa1: 2alf A:2-165 [126975]
  complexed with mg; mutant
Domain for 2cpl:
- Domain d2cpla_: 2cpl A: [27420]
Domain for 2cyh:
- Domain d2cyha_: 2cyh A: [27421]
Domains for 2rma:
1. Domain d2rmaa_: 2rma A: [27435]
2. Domain d2rmac_: 2rma C: [27436]
3. Domain d2rmae_: 2rma E: [27437]
4. Domain d2rmag_: 2rma G: [27438]
5. Domain d2rmai_: 2rma I: [27439]
6. Domain d2rmak_: 2rma K: [27440]
7. Domain d2rmam_: 2rma M: [27441]
8. Domain d2rmao_: 2rma O: [27442]
9. Domain d2rmaq_: 2rma Q: [27443]
10. Domain d2rmas_: 2rma S: [27444]
  complexed with aba
Domains for 2rmb:
1. Domain d2rmba_: 2rmb A: [27446]
2. Domain d2rmbc_: 2rmb C: [27447]
3. Domain d2rmbe_: 2rmb E: [27448]
4. Domain d2rmbg_: 2rmb G: [27449]
5. Domain d2rmbi_: 2rmb I: [27450]
6. Domain d2rmbk_: 2rmb K: [27451]
7. Domain d2rmbm_: 2rmb M: [27452]
8. Domain d2rmbo_: 2rmb O: [27453]
9. Domain d2rmbq_: 2rmb Q: [27454]
10. Domain d2rmbs_: 2rmb S: [27455]
  complexed with aba, dmt
Domain for 3cyh:
- Domain d3cyha_: 3cyh A: [27432]
Domain for 3cys:
- Domain d3cysa_: 3cys A: [27488]
  complexed with aba
Domain for 4cyh:
- Domain d4cyha_: 4cyh A: [27457]
Domain for 5cyh:
- Domain d5cyha_: 5cyh A: [27460]

Human (Homo sapiens), variant B [TaxId:9606] [50895] (1 PDB entry)
- Domain for 1cyn:
  - Domain d1cyna_: 1cyn A: [27489]
    complexed with aba
Human (Homo sapiens), variant C [TaxId:9606] [141498] (1 PDB entry)
- Domains for 2esl:
  1. Domain d2esla1: 2esl A:32-212 [132327]
    complexed with aba, ca, so4, zn
  2. Domain d2eslb1: 2esl B:32-212 [132328]
    automatically matched to 2ESL A:32-212
    complexed with aba, ca, so4, zn
  3. Domain d2eslc1: 2esl C:32-212 [132329]
    automatically matched to 2ESL A:32-212
    complexed with aba, ca, so4, zn
  4. Domain d2esld1: 2esl D:32-212 [132330]
    automatically matched to 2ESL A:32-212
    complexed with aba, ca, so4, zn
  5. Domain d2esle1: 2esl E:32-212 [132331]
    automatically matched to 2ESL A:32-212
    complexed with aba, ca, so4, zn
  6. Domain d2eslf1: 2esl F:32-212 [132332]
    automatically matched to 2ESL A:32-212
    complexed with aba, ca, so4, zn
Mouse (Mus musculus), variant C [TaxId:10090] [50897] (1 PDB entry)
- Domains for 2rmc:
  1. Domain d2rmca_: 2rmc A: [27491]
  2. Domain d2rmcc_: 2rmc C: [27492]
  3. Domain d2rmce_: 2rmc E: [27493]
  4. Domain d2rmcg_: 2rmc G: [27494]
    complexed with aba
Nematode (Brugia malayi) [TaxId:6279] [50898] (3 PDB entries)
1. Domain for 1a33:
  - Domain d1a33a_: 1a33 A: [27496]
2. Domain for 1a58:
  - Domain d1a58a_: 1a58 A: [27495]
3. Domains for 1c5f:
  1. Domain d1c5fa_: 1c5f A: [27497]
  2. Domain d1c5fc_: 1c5f C: [27498]
  3. Domain d1c5fe_: 1c5f E: [27499]
  4. Domain d1c5fg_: 1c5f G: [27500]
  5. Domain d1c5fi_: 1c5f I: [27501]
  6. Domain d1c5fk_: 1c5f K: [27502]
  7. Domain d1c5fm_: 1c5f M: [27503]
  8. Domain d1c5fo_: 1c5f O: [27504]
Plasmodium falciparum [TaxId:5833] [50900] (2 PDB entries)
1. Domain for 1qng:
  - Domain d1qnga_: 1qng A: [27507]
    complexed with aba
2. Domains for 1qnh:
  1. Domain d1qnha_: 1qnh A: [27508]
  2. Domain d1qnhb_: 1qnh B: [27509]
    complexed with aba; mutant
Plasmodium yoelii [TaxId:5861] [141500] (1 PDB entry)
- Domain for 1z81:
  - Domain d1z81a1: 1z81 A:25-210 [124685]
Trypanosoma cruzi [TaxId:5693] [117269] (2 PDB entries)
1. Domains for 1xo7:
  1. Domain d1xo7a_: 1xo7 A: [115694]
  2. Domain d1xo7b_: 1xo7 B: [115695]
  3. Domain d1xo7c_: 1xo7 C: [115696]
  4. Domain d1xo7d_: 1xo7 D: [115697]
    Structural genomics target
2. Domains for 1xq7:
  1. Domain d1xq7a_: 1xq7 A: [115831]
  2. Domain d1xq7b_: 1xq7 B: [115832]
  3. Domain d1xq7c_: 1xq7 C: [115833]
    Structural genomics target
    complexed with aba

More info for Protein Cyclophilin (eukaryotic) from b.62.1.1: Cyclophilin (peptidylprolyl isomerase)

Timeline for Protein Cyclophilin (eukaryotic) from b.62.1.1: Cyclophilin (peptidylprolyl isomerase):

Protein Cyclophilin (eukaryotic) from b.62.1.1: Cyclophilin (peptidylprolyl isomerase) first appeared (with stable ids) in SCOP 1.55
Protein Cyclophilin (eukaryotic) from b.62.1.1: Cyclophilin (peptidylprolyl isomerase) appears in SCOP 1.71
Protein Cyclophilin (eukaryotic) from b.62.1.1: Cyclophilin (peptidylprolyl isomerase) appears in SCOP 1.75
Protein Cyclophilin (eukaryotic) from b.62.1.1: Cyclophilin (peptidylprolyl isomerase) appears in the current release, SCOPe 2.08