Lineage for Family b.22.1.1: TNF-like

  1. Root: SCOPe 2.06
  2. 2017114Class b: All beta proteins [48724] (177 folds)
  3. 2041369Fold b.22: TNF-like [49841] (1 superfamily)
    sandwich, 10 strands in 2 sheets; jelly-roll
  4. 2041370Superfamily b.22.1: TNF-like [49842] (2 families) (S)
  5. 2041371Family b.22.1.1: TNF-like [49843] (15 protein domains)

Protein Domains:

  1. 204137230 kDa adipocyte complement-related protein [49846] (1 species)
  2. 2041383A proliferation-inducing ligand, APRIL [117117] (1 species)
  3. 2041396Apoptosis-2 ligand, apo2l/TRAIL [49851] (1 species)
  4. 2041410Collagen NC1 trimerisation domain [69230] (2 species)
    1. 2041411Species Human (Homo sapiens), isoform X [TaxId:9606] [69231] (1 PDB entry)
    2. 2041413Species Mouse (Mus musculus), isoform VIII [TaxId:10090] [101612] (1 PDB entry)
  5. 2041417Complement c1q globular head, A chain [101613] (1 species)
    hetrotrimer of A, B and C chains
  6. 2041428Complement c1q globular head, B chain [101615] (1 species)
    hetrotrimer of A, B and C chains
  7. 2041435Complement c1q globular head, C chain [101617] (1 species)
    hetrotrimer of A, B and C chains
  8. 2041446Ectodysplasin A, Eda-a1 [101610] (1 species)
  9. 2041466Extracellular domain of CD40 ligand [49844] (1 species)
  10. 2041472Glucocorticoid-induced TNF-related ligand, TNFSF18 [158982] (4 species)
    1. 2041473Species Human (Homo sapiens) [TaxId:9606] [158984] (5 PDB entries)
      Uniprot Q9UNG2 55-177! Uniprot Q9UNG2 57-172! Uniprot Q9UNG2 57-176
    2. 2041484Species Mouse (Mus musculus) [TaxId:10090] [158983] (4 PDB entries)
      Uniprot Q7TS55 51-173! Uniprot Q80YG2 49-173
    3. 2041493Species Ochotona princeps [TaxId:9978] [195782] (1 PDB entry)
    4. 2041500Species Otolemur garnettii [TaxId:30611] [194874] (1 PDB entry)
  11. 2041502Soluble part of TALL-1, sTALL-1 (BAFF) [69228] (1 species)
    • 2041503Species Human (Homo sapiens) [TaxId:9606] [69229] (6 PDB entries)
      also includes the PDB entry (1otz) that together with the entry (1p0t) provides the multimeric structure of the complex of this protein with its receptor, BAFF-R. In these entries protein chains are designated by both upper case and lower case letters creating problems with its processing and presentation in SCOP
  12. 2041552TRANCE/RANKL cytokine [63721] (1 species)
  13. 2041568Tumor necrosis factor (TNF) [49848] (2 species)
    1. 2041569Species Human (Homo sapiens) [TaxId:9606] [49849] (19 PDB entries)
    2. 2041615Species Mouse (Mus musculus) [TaxId:10090] [49850] (1 PDB entry)
  14. 2041619Tumor necrosis factor ligand superfamily member 4, OX40L [141127] (2 species)
    1. 2041620Species Human (Homo sapiens) [TaxId:9606] [141128] (1 PDB entry)
      Uniprot P23510 58-183
    2. 2041622Species Mouse (Mus musculus) [TaxId:10090] [141129] (2 PDB entries)
      Uniprot P43488 58-185
  15. 2041626automated matches [190204] (3 species)
    not a true protein
    1. 2041627Species Human (Homo sapiens) [TaxId:9606] [186956] (11 PDB entries)
    2. 2041653Species Mouse (Mus musculus) [TaxId:10090] [189134] (3 PDB entries)
    3. 2041659Species Rabbit (Oryctolagus cuniculus) [TaxId:9986] [195809] (1 PDB entry)

More info for Family b.22.1.1: TNF-like

Timeline for Family b.22.1.1: TNF-like: