SCOPe 2.03: Family a.100.1.1: Hydroxyisobutyrate and 6-phosphogluconate dehydrogenase domain

Lineage for Family a.100.1.1: Hydroxyisobutyrate and 6-phosphogluconate dehydrogenase domain

1. Root: SCOPe 2.03

2. Class a: All alpha proteins [46456] (284 folds)

3. Fold a.100: 6-phosphogluconate dehydrogenase C-terminal domain-like [48178] (1 superfamily)
   multihelical; common core is formed around two long antiparallel helices related by (pseudo) twofold symmetry

4. Superfamily a.100.1: 6-phosphogluconate dehydrogenase C-terminal domain-like [48179] (13 families)
   N-terminal domain is Rossmann-fold with a family-specific C-terminal extension

5. Family a.100.1.1: Hydroxyisobutyrate and 6-phosphogluconate dehydrogenase domain [48180] (3 proteins)
   Hydroxyisobutyrate dehydrogenase domain is similar to one structural repeat in the 6-phosphogluconate dehydrogenase domain

Proteins:

1. 6-phosphogluconate dehydrogenase (6PGD) [48181] (2 species)
   duplication; contains two structural repeats

   1. Species Sheep (Ovis orientalis aries) [TaxId:9940] [48182] (5 PDB entries)

   2. Species Trypanosome (Trypanosoma brucei) [TaxId:5691] [48183] (1 PDB entry)

2. Hydroxyisobutyrate dehydrogenase [101357] (3 species)
   forms similar dimeric and tetrameric structures to the 6-phosphogluconate dehydrogenase domain and its dimer, respectively

   1. Species Pseudomonas aeruginosa [TaxId:287] [158733] (2 PDB entries)
      Uniprot Q9I5I6 163-296

   2. Species Salmonella typhimurium [TaxId:90371] [109948] (1 PDB entry)
      Uniprot Q8ZLV8

   3. Species Thermus thermophilus [TaxId:274] [101358] (2 PDB entries)
      structural genomics

3. automated matches [227013] (1 species)
   not a true protein

   • Species Human (Homo sapiens) [TaxId:9606] [225747] (2 PDB entries)

More info for Family a.100.1.1: Hydroxyisobutyrate and 6-phosphogluconate dehydrogenase domain

Timeline for Family a.100.1.1: Hydroxyisobutyrate and 6-phosphogluconate dehydrogenase domain:

• Family a.100.1.1: Hydroxyisobutyrate and 6-phosphogluconate dehydrogenase domain first appeared (with stable ids) in SCOP 1.55, called Family a.100.1.1: 6-phosphogluconate dehydrogenase (6PGD)
  
• Family a.100.1.1: Hydroxyisobutyrate and 6-phosphogluconate dehydrogenase domain appears in SCOPe 2.02
  
• Family a.100.1.1: Hydroxyisobutyrate and 6-phosphogluconate dehydrogenase domain appears in SCOPe 2.04
  
• Family a.100.1.1: Hydroxyisobutyrate and 6-phosphogluconate dehydrogenase domain appears in the current release, SCOPe 2.08