SCOPe Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Three proposals to the NIH for continued funding have been unsuccessful. If our current NIH proposal is not funded, SCOPe will shut down permanently in Summer 2017 as Dr. Chandonia will need to seek a new position.

Lineage for Fold a.39: EF Hand-like

  1. Root: SCOPe 2.06
  2. 1976409Class a: All alpha proteins [46456] (289 folds)
  3. 1994319Fold a.39: EF Hand-like [47472] (4 superfamilies)
    core: 4 helices; array of 2 hairpins, opened

Superfamilies:

  1. 1994320a.39.1: EF-hand [47473] (12 families) (S)
    Duplication: consists of two EF-hand units: each is made of two helices connected with calcium-binding loop
  2. 1995815a.39.2: Insect pheromone/odorant-binding proteins [47565] (2 families) (S)
    the N-terminal extension, containing a few short helices, forms a flexible lid for the binding cavity
  3. 1995943a.39.3: Cloroperoxidase [47571] (1 family) (S)
    duplication: consists of 2 similar domains composed of 2 EF hand-like motifs each
  4. 1995973a.39.4: Hypothetical protein MTH865 [69025] (1 family) (S)
    automatically mapped to Pfam PF07747

More info for Fold a.39: EF Hand-like

Timeline for Fold a.39: EF Hand-like: