SCOPe Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Three proposals to the NIH for continued funding have been unsuccessful. If our current NIH proposal is not funded, SCOPe will shut down permanently in Summer 2017 as Dr. Chandonia will need to seek a new position.

Lineage for Family a.22.1.3: TBP-associated factors, TAFs

  1. Root: SCOPe 2.06
  2. 1976409Class a: All alpha proteins [46456] (289 folds)
  3. 1986516Fold a.22: Histone-fold [47112] (1 superfamily)
    core: 3 helices; long middle helix is flanked at each end with shorter ones
  4. 1986517Superfamily a.22.1: Histone-fold [47113] (5 families) (S)
  5. 1987129Family a.22.1.3: TBP-associated factors, TAFs [47134] (14 protein domains)

Protein Domains:

  1. 1987130Chrac-14 [140398] (1 species)
  2. 1987136Chrac-16 [140400] (1 species)
  3. 1987142Histone domain of Son of sevenless protein [101107] (1 species)
  4. 1987153Negative cofactor 2, NC2, alpha chain [63507] (1 species)
  5. 1987156Negative cofactor 2, NC2, beta chain [63509] (1 species)
  6. 1987159Nuclear transcription factor Y subunit beta (Nf-Yb3) [81724] (1 species)
    forms a heterodimer with Nf-Yc2 similar to H2A/H2B
  7. 1987162Nuclear transcription factor Y subunit gamma (Nf-Yc2) [81726] (1 species)
    forms a heterodimer with Nf-Yb3 similar to H2A/H2B
  8. 1987165TAF(II)-135, (TAF(II)-130, hTAF4), histone fold domain [81720] (1 species)
    lacks the third helix, forms a heterodimer with TAF(II)-20 similar to H2A-H2B
  9. 1987169TAF(II)-20, (TAF(II)-15, hTAF12), histone fold domain [81722] (1 species)
    forms a heterodimer with TAF(II)-135 similar to H2A-H2B
  10. 1987173TAF(II)18 [47139] (1 species)
  11. 1987177TAF(II)28 [47141] (1 species)
  12. 1987181TAF(II)42 [47135] (1 species)
    TAFii42 and TAFii62 form heterotetramer similar to (H3-H4)2
  13. 1987184TAF(II)62 [47137] (1 species)
    TAFii42 and TAFii62 form heterotetramer similar to (H3-H4)2
  14. 1987187automated matches [194413] (3 species)
    not a true protein
    1. 1987188Species Aspergillus nidulans [TaxId:227321] [194414] (2 PDB entries)
    2. 1987191Species Human (Homo sapiens) [TaxId:9606] [270229] (1 PDB entry)
    3. 2283597Species Arabidopsis thaliana [TaxId:3702] [326898] (1 PDB entry)

More info for Family a.22.1.3: TBP-associated factors, TAFs

Timeline for Family a.22.1.3: TBP-associated factors, TAFs: