Lineage for d1pme__ (1pme -)

  1. Root: SCOP 1.65
  2. 323018Class d: Alpha and beta proteins (a+b) [53931] (234 folds)
  3. 334933Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
    consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
  4. 334934Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (6 families) (S)
    shares functional and structural similarities with the ATP-grasp fold and PIPK
  5. 334971Family d.144.1.7: Protein kinases, catalytic subunit [88854] (41 proteins)
    members organised in the groups and subfamiles specified by the comments
  6. 335225Protein MAP kinase Erk2 [56134] (2 species)
    CMGC group; ERK/MAPK subfamily; serine/threonine kinase
  7. 335226Species Human (Homo sapiens) [TaxId:9606] [56135] (1 PDB entry)
  8. 335227Domain d1pme__: 1pme - [41653]
    complexed with 577, so4; mutant

Details for d1pme__

PDB Entry: 1pme (more details), 2 Å

PDB Description: structure of penta mutant human erk2 map kinase complexed with a specific inhibitor of human p38 map kinase

SCOP Domain Sequences for d1pme__:

Sequence, based on SEQRES records: (download)

>d1pme__ d.144.1.7 (-) MAP kinase Erk2 {Human (Homo sapiens)}
gqvfdvgprytnlsyigegaygmvcsaydnvnkvrvaikkispfehqtycqrtlreikil
lrfrheniigindiiraptieqmkdvylvthlmgadlykllktqhlsndhicyflyqilr
glkyihsanvlhrdlkpsnlllnttcdlkicdfglarvadpdhdhtgflteyvatrwyra
peimlnskgytksidiwsvgcilaemlsnrpifpgkhyldqlnhilgilgspsqedlnci
inlkarnyllslphknkvpwnrlfpnadskaldlldkmltfnphkrieveqalahpyleq
yydpsdepiaeapfkfdmelddlpkeklkelifeetarfqpgyrs

Sequence, based on observed residues (ATOM records): (download)

>d1pme__ d.144.1.7 (-) MAP kinase Erk2 {Human (Homo sapiens)}
gqvfdvgprytnlsyigygmvcsaydnvnkvrvaikkispfehqtycqrtlreikillrf
rheniigindiiraptieqmkdvylvthlmgadlykllktqhlsndhicyflyqilrglk
yihsanvlhrdlkpsnlllnttcdlkicdfglarvadpdhdhtgflteyvatrwyrapei
mlnskgytksidiwsvgcilaemlsnrpifpgkhyldqlnhilgilgspsqedlnciinl
karnyllslphknkvpwnrlfpnadskaldlldkmltfnphkrieveqalahpyleqyyd
psdepiaeapflpkeklkelifeetarfqpgyrs

SCOP Domain Coordinates for d1pme__:

Click to download the PDB-style file with coordinates for d1pme__.
(The format of our PDB-style files is described here.)

Timeline for d1pme__: