SCOPe 2.07: Domain d7c3gb_: 7c3g B:

Lineage for d7c3gb_ (7c3g B:)

1. Root: SCOPe 2.07

2. Class d: Alpha and beta proteins (a+b) [53931] (388 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein automated matches [190091] (20 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [188447] (892 PDB entries)

8. Domain d7c3gb_: 7c3g B: [398604]
   automated match to d6eixa_
   complexed with edo, fh0, so4; mutant

Details for d7c3gb_

PDB Entry: 7c3g, 1.8 Å

PDB Description: crystal structure of human alk2 kinase domain with r206h mutation in complex with a bicyclic pyrazole inhibitor rk-73134

PDB Compounds: (B:) Activin receptor type-1

SCOPe Domain Sequences for d7c3gb_:

Sequence, based on SEQRES records:

>d7c3gb_ d.144.1.7 (B:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
vahqitllecvgkgrygevwrgswqgenvavkifssrdekswfretelyntvmlrhenil
gfiasdmtsrhsstqlwlithyhemgslydylqlttldtvsclrivlsiasglahlhiei
fgtqgkpaiahrdlksknilvkkngqcciadlglavmhsqstnqldvgnnprvgtkryma
pevldetiqvdcfdsykrvdiwafglvlwevarrmvsngivedykppfydvvpndpsfed
mrkvvcvdqqrpnipnrwfsdptltslaklmkecwyqnpsarltalrikktltkid

Sequence, based on observed residues (ATOM records):

>d7c3gb_ d.144.1.7 (B:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
vahqitllecvgkgrygevwrgswqgenvavkifssrdekswfretelyntvmlrhenil
gfiasdmtsrstqlwlithyhemgslydylqlttldtvsclrivlsiasglahlhieifg
gkpaiahrdlksknilvkkngqcciadlglavmhsqstnqldvgnnprvgtkrymapevl
detiqvdcfdsykrvdiwafglvlwevarrmvsngivedykppfydvvpndpsfedmrkv
vcvdqqrpnipnrwfsdptltslaklmkecwyqnpsarltalrikktltkid

Timeline for d7c3gb_:

• d7c3gb_ is new in SCOPe 2.07-stable
  
• d7c3gb_ appears in the current release, SCOPe 2.08