SCOPe 2.07: Domain d7axha_: 7axh A:

Lineage for d7axha_ (7axh A:)

1. Root: SCOPe 2.07

2. Class a: All alpha proteins [46456] (289 folds)

3. Fold a.123: Nuclear receptor ligand-binding domain [48507] (1 superfamily)
   multihelical; 3 layers or orthogonally packed helices

4. Superfamily a.123.1: Nuclear receptor ligand-binding domain [48508] (2 families)

5. Family a.123.1.1: Nuclear receptor ligand-binding domain [48509] (34 proteins)

6. Protein Pregnane x receptor, PXR [63624] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [63625] (31 PDB entries)

8. Domain d7axha_: 7axh A: [398315]
   automated match to d1m13a_
   complexed with 27j, ipa, mpd

Details for d7axha_

PDB Entry: 7axh, 2.55 Å

PDB Description: crystal structure of the hpxr-lbd in complex with alpha-zearalanol

PDB Compounds: (A:) Nuclear receptor subfamily 1 group I member 2

SCOPe Domain Sequences for d7axha_:

Sequence, based on SEQRES records:

>d7axha_ a.123.1.1 (A:) Pregnane x receptor, PXR {Human (Homo sapiens) [TaxId: 9606]}
qglteeqrmmirelmdaqmktfdttfshfknfrlpgvlssgcelpeslqapsreeaakws
qvrkdlcslkvslqlrgedgsvwnykppadsggkeifsllphmadmstymfkgiisfakv
isyfrdlpiedqisllkgaafelcqlrfntvfnaetgtwecgrlsycledtaggfqqlll
epmlkfhymlkklqlheeeyvlmqaislfspdrpgvlqhrvvdqlqeqfaitlksyiecn
rpqpahrflflkimamltelrsinaqhtqrllriqdihpfatplmqelfgitgs

Sequence, based on observed residues (ATOM records):

>d7axha_ a.123.1.1 (A:) Pregnane x receptor, PXR {Human (Homo sapiens) [TaxId: 9606]}
qglteeqrmmirelmdaqmktfdttfshfknfrlpgvaakwsqvrkdlcslkvslqlrge
dgsvwnykppadsggkeifsllphmadmstymfkgiisfakvisyfrdlpiedqisllkg
aafelcqlrfntvfnaetgtwecgrlsycledfqqlllepmlkfhymlkklqlheeeyvl
mqaislfspdrpgvlqhrvvdqlqeqfaitlksyiecnrpqpahrflflkimamltelrs
inaqhtqrllriqdihpfatplmqelfgitgs

Timeline for d7axha_:

• d7axha_ is new in SCOPe 2.07-stable
  
• d7axha_ appears in the current release, SCOPe 2.08