SCOPe 2.07: Domain d6vcjd_: 6vcj D:

Lineage for d6vcjd_ (6vcj D:)

1. Root: SCOPe 2.07

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.71: Dihydrofolate reductase-like [53596] (1 superfamily)
   3 layers: a/b/a; mixed beta-sheet of 8 strands, order 34251687; strand 8 is antiparallel to the rest

4. Superfamily c.71.1: Dihydrofolate reductase-like [53597] (3 families)

5. Family c.71.1.1: Dihydrofolate reductases [53598] (4 proteins)

6. Protein Dihydrofolate reductases, eukaryotic type [53605] (7 species)

7. Species Human (Homo sapiens) [TaxId:9606] [53607] (79 PDB entries)

8. Domain d6vcjd_: 6vcj D: [395988]
   automated match to d1kmva_
   complexed with fol, lg3, nap, npx

Details for d6vcjd_

PDB Entry: 6vcj, 2.34 Å

PDB Description: crystal structure of hsdhfr in complex with nadp+, dap, and r-naproxen

PDB Compounds: (D:) dihydrofolate reductase

SCOPe Domain Sequences for d6vcjd_:

Sequence, based on SEQRES records:

>d6vcjd_ c.71.1.1 (D:) Dihydrofolate reductases, eukaryotic type {Human (Homo sapiens) [TaxId: 9606]}
gslncivavsqnmgigkngdlpwpplrnefryfqrmtttssvegkqnlvimgkktwfsip
eknrplkgrinlvlsrelkeppqgahflsrslddalklteqpelankvdmvwivggssvy
keamnhpghlklfvtrimqdfesdtffpeidlekykllpeypgvlsdvqeekgikykfev
yeknd

Sequence, based on observed residues (ATOM records):

>d6vcjd_ c.71.1.1 (D:) Dihydrofolate reductases, eukaryotic type {Human (Homo sapiens) [TaxId: 9606]}
gslncivavsqnmgigkngdlpwpplrnefryfqrmtttssvegkqnlvimgkktwfsip
eknrplkgrinlvlsrelkeppqgahflsrslddalklteqelankvdmvwivggssvyk
eamnhpghlklfvtrimqdfesdtffpeidlekykllpeypgvlsdvqeekgikykfevy
eknd

Timeline for d6vcjd_:

• d6vcjd_ is new in SCOPe 2.07-stable
  
• d6vcjd_ appears in the current release, SCOPe 2.08