SCOPe 2.07: Domain d6wl6a_: 6wl6 A:

Lineage for d6wl6a_ (6wl6 A:)

1. Root: SCOPe 2.07

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.31: DHS-like NAD/FAD-binding domain [52466] (1 superfamily)
   3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456; Rossmann-like

4. Superfamily c.31.1: DHS-like NAD/FAD-binding domain [52467] (7 families)
   binds cofactor molecules in the opposite direction than classical Rossmann fold

5. Family c.31.1.1: Deoxyhypusine synthase, DHS [52468] (2 proteins)
   automatically mapped to Pfam PF01916

6. Protein Deoxyhypusine synthase, DHS [52469] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [52470] (13 PDB entries)
   Uniprot P49366

8. Domain d6wl6a_: 6wl6 A: [393006]
   automated match to d1dhsa_
   complexed with 91a

Details for d6wl6a_

PDB Entry: 6wl6, 2.12 Å

PDB Description: cocomplex structure of deoxyhypusine synthase with inhibitor 6-[(2r)- 1-amino-4-methylpentan-2-yl]-3-(pyridin-3-yl)-4h,5h,6h,7h-thieno[2,3- c]pyridin-7-one

PDB Compounds: (A:) deoxyhypusine synthase

SCOPe Domain Sequences for d6wl6a_:

Sequence, based on SEQRES records:

>d6wl6a_ c.31.1.1 (A:) Deoxyhypusine synthase, DHS {Human (Homo sapiens) [TaxId: 9606]}
stqvrgydfnrgvnyralleafgttgfqatnfgravqqvnamiekkleplsqdedqhadl
tqsrrpltsctiflgytsnlissgiretirylvqhnmvdvlvttaggveedlikclapty
lgefslrgkelrenginrignllvpnenyckfedwlmpildqmvmeqntegvkwtpskmi
arlgkeinnpesvyywaqknhipvfspaltdgslgdmiffhsyknpglvldivedlrlin
tqaifakctgmiilgggvvkhhiananlmrngadyavyintaqefdgsdsgarpdeavsw
gkirvdaqpvkvyadaslvfpllvaetfaqkmdafm

Sequence, based on observed residues (ATOM records):

>d6wl6a_ c.31.1.1 (A:) Deoxyhypusine synthase, DHS {Human (Homo sapiens) [TaxId: 9606]}
stqvrgydfnrgvnyralleafgttgfqatnfgravqqvnamiekkleplsqdedqrrpl
tsctiflgytsnlissgiretirylvqhnmvdvlvttaggveedlikclaptylgefgin
rignllvpnenyckfedwlmpildqmvmeqntegvkwtpskmiarlgkeinnpesvyywa
qknhipvfspaltdgslgdmiffhsyknpglvldivedlrlintqaifakctgmiilggg
vvkgadyavyintaqefdgsqpvkvyadaslvfpllvaetfaqkmdafm

Timeline for d6wl6a_:

• d6wl6a_ is new in SCOPe 2.07-stable
  
• d6wl6a_ appears in the current release, SCOPe 2.08