SCOPe 2.07: Domain d6pfab1: 6pfa B:3-179

Lineage for d6pfab1 (6pfa B:3-179)

1. Root: SCOPe 2.07

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.71: Dihydrofolate reductase-like [53596] (1 superfamily)
   3 layers: a/b/a; mixed beta-sheet of 8 strands, order 34251687; strand 8 is antiparallel to the rest

4. Superfamily c.71.1: Dihydrofolate reductase-like [53597] (3 families)

5. Family c.71.1.1: Dihydrofolate reductases [53598] (4 proteins)

6. Protein Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, DFR domain [53610] (2 species)

7. Species Cryptosporidium hominis [TaxId:237895] [102636] (15 PDB entries)
   Uniprot Q5CGA3 Q27552

8. Domain d6pfab1: 6pfa B:3-179 [375032]
   Other proteins in same PDB: d6pfaa2, d6pfab2, d6pfac2, d6pfad2, d6pfae2
   automated match to d1qzfa1
   complexed with mtx, ndp, of4, so4, ufp

Details for d6pfab1

PDB Entry: 6pfa, 2.79 Å

PDB Description: crystal structure of ts-dhfr from cryptosporidium hominis in complex with nadph, fdump and 2-((4-((2-amino-4-oxo-4,7-dihydro-3h-pyrrolo[2, 3-d]pyrimidin-5-yl)methyl)benzamido)methyl)benzoic acid.

PDB Compounds: (B:) Bifunctional dihydrofolate reductase-thymidylate synthase

SCOPe Domain Sequences for d6pfab1:

Sequence; same for both SEQRES and ATOM records:

>d6pfab1 c.71.1.1 (B:3-179) Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, DFR domain {Cryptosporidium hominis [TaxId: 237895]}
eknvsivvaasvlssgigingqlpwsisedlkffskitnnkcdsnkknalimgrktwdsi
grrplknriivvissslpqdeadpnvvvfrnledsienlmnddsienifvcggesiyrda
lkdnfvdriyltrvalediefdtyfpeipetflpvymsqtfctknisydfmifekqe

Timeline for d6pfab1:

• d6pfab1 is new in SCOPe 2.07-stable
  
• d6pfab1 appears in the current release, SCOPe 2.08