SCOPe 2.07: Domain d6j3ca_: 6j3c A:

Lineage for d6j3ca_ (6j3c A:)

1. Root: SCOPe 2.07

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.1: TIM beta/alpha-barrel [51350] (33 superfamilies)
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites

4. Superfamily c.1.4: FMN-linked oxidoreductases [51395] (2 families)

5. Family c.1.4.1: FMN-linked oxidoreductases [51396] (19 proteins)

6. Protein Dihydroorotate dehydrogenase [51397] (8 species)

7. Species Human (Homo sapiens) [TaxId:9606] [51400] (68 PDB entries)

8. Domain d6j3ca_: 6j3c A: [373171]
   automated match to d3kvma_
   complexed with b5x, fmn, lda, oro, so4

Details for d6j3ca_

PDB Entry: 6j3c, 1.85 Å

PDB Description: crystal structure of human dhodh in complex with inhibitor 1291

PDB Compounds: (A:) Dihydroorotate dehydrogenase (quinone), mitochondrial

SCOPe Domain Sequences for d6j3ca_:

Sequence, based on SEQRES records:

>d6j3ca_ c.1.4.1 (A:) Dihydroorotate dehydrogenase {Human (Homo sapiens) [TaxId: 9606]}
atgderfyaehlmptlqglldpesahrlavrftslgllprarfqdsdmlevrvlghkfrn
pvgiaagfdkhgeavdglykmgfgfveigsvtpkpqegnprprvfrlpedqavinrygfn
shglsvvehrlrarqqkqakltedglplgvnlgknktsvdaaedyaegvrvlgpladylv
vnvsspntaglrslqgkaelrrlltkvlqerdglrrvhrpavlvkiapdltsqdkedias
vvkelgidglivtnttvsrpaglqgalrsetgglsgkplrdlstqtiremyaltqgrvpi
igvggvssgqdalekiragaslvqlytaltfwgppvvgkvkreleallkeqgfggvtdai
gadhrr

Sequence, based on observed residues (ATOM records):

>d6j3ca_ c.1.4.1 (A:) Dihydroorotate dehydrogenase {Human (Homo sapiens) [TaxId: 9606]}
atgderfyaehlmptlqglldpesahrlavrftslgllpfqdsdmlevrvlghkfrnpvg
iaagfdkhgeavdglykmgfgfveigsvtpkpqegnprprvfrlpedqavinrygfnshg
lsvvehrlrarqqkqakltedglplgvnlgknktsvdaaedyaegvrvlgpladylvvnv
sspntaglrslqgkaelrrlltkvlqerdglrrvhrpavlvkiapdltsqdkediasvvk
elgidglivtnttvsrpaglqgalrsetgglsgkplrdlstqtiremyaltqgrvpiigv
ggvssgqdalekiragaslvqlytaltfwgppvvgkvkreleallkeqgfggvtdaigad
hrr

Timeline for d6j3ca_:

• d6j3ca_ is new in SCOPe 2.07-stable
  
• d6j3ca_ appears in the current release, SCOPe 2.08