SCOPe 2.07: Domain d6nzpb_: 6nzp B:

Lineage for d6nzpb_ (6nzp B:)

1. Root: SCOPe 2.07

2. Class d: Alpha and beta proteins (a+b) [53931] (388 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.0: automated matches [191359] (1 protein)
   not a true family

6. Protein automated matches [190417] (35 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187294] (1319 PDB entries)

8. Domain d6nzpb_: 6nzp B: [372395]
   automated match to d3zona_
   complexed with cl, lb7

Details for d6nzpb_

PDB Entry: 6nzp, 2.35 Å

PDB Description: crystal structure of tyrosine kinase 2 jh2 (pseudo kinase domain) complexed with compound-11 aka 6-cyclopropaneamido-4-{[2-methoxy-3- (1-methyl-1h-1,2,4-tri azol-3-yl)phenyl]amino}-n-(?h?) methylpyridazine-3-carboxamide

PDB Compounds: (B:) Non-receptor tyrosine-protein kinase TYK2

SCOPe Domain Sequences for d6nzpb_:

Sequence, based on SEQRES records:

>d6nzpb_ d.144.1.0 (B:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
sfhrvdqkeitqlshlgqgtrtnvyegrlrvegsgdpeegkmddedplvpgrdrgqelrv
vlkvldpshhdialafyetaslmsqvshthlafvhgvcvrgpenimvteyvehgpldvwl
rrerghvpmawkmvvaqqlasalsylenknlvhgnvcgrnillarlglaegtspfiklsd
pgvglgalsreerveripwlapeclpgganslstamdkwgfgatlleicfdgeaplqsrs
psekehfyqrqhrlpepscpqlatltsqcltyeptqrpsfrtilrdltr

Sequence, based on observed residues (ATOM records):

>d6nzpb_ d.144.1.0 (B:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
sfhrvdqkeitqlshlgqgtrtnvyegrlrvqelrvvlkvldpshhdialafyetaslms
qvshthlafvhgvcvrgpenimvteyvehgpldvwlrrerghvpmawkmvvaqqlasals
ylenknlvhgnvcgrnillarlglaegtspfiklsdpgvglgalsreerveripwlapec
lplstamdkwgfgatlleicfdgeaplqsrspsekehfyqrqhrlpepscpqlatltsqc
ltyeptqrpsfrtilrdltr

Timeline for d6nzpb_:

• d6nzpb_ is new in SCOPe 2.07-stable
  
• d6nzpb_ appears in the current release, SCOPe 2.08