SCOPe 2.07: Domain d6npnc_: 6npn C:

Lineage for d6npnc_ (6npn C:)

1. Root: SCOPe 2.07

2. Class d: Alpha and beta proteins (a+b) [53931] (388 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.0: automated matches [191359] (1 protein)
   not a true family

6. Protein automated matches [190417] (35 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187294] (1319 PDB entries)

8. Domain d6npnc_: 6npn C: [365232]
   automated match to d6bu6a_
   complexed with edo, kwj, peg, so4

Details for d6npnc_

PDB Entry: 6npn, 2.2 Å

PDB Description: crystal structure of the human vaccinia-related kinase bound to a n,n- dipropynyl-dihydropteridine-3-hydroxyindazole inhibitor

PDB Compounds: (C:) Serine/threonine-protein kinase VRK1

SCOPe Domain Sequences for d6npnc_:

Sequence, based on SEQRES records:

>d6npnc_ d.144.1.0 (C:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
eqfavgeiitdmaaaawkvglpigqggfgciyladmnssesvgsdapcvvkvepsdngpl
ftelkfyqraakpeqiqkwirtrklkylgvpkywgsglhdkngksyrfmimdrfgsdlqk
iyeanakrfsrktvlqlslrildileyiheheyvhgdikasnlllnyknpdqvylvdygl
ayrycpegvhkayaadpkrchdgtieftsidahngvapsrrgdleilgycmiqwltghlp
wednlkdpkyvrdskiryreniaslmdkcfpaanapgeiakymetvklldytekplyenl
rdillqglkaigskddgkldl

Sequence, based on observed residues (ATOM records):

>d6npnc_ d.144.1.0 (C:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
eqfavgeiitdmaaaawkvglpiciyladmnssesvgsdapcvvkvepsdngplftelkf
yqraakpeqiqkwirtrklkylgvpkywgsglhdkngksyrfmimdrfgsdlqkiyeana
krfsrktvlqlslrildileyiheheyvhgdikasnlllnyknpdqvylvdyglayrycp
egvhkayaadpkrchdgtieftsidahngvapsrrgdleilgycmiqwltghlpwednlk
dpkyvrdskiryreniaslmdkcfpaanapgeiakymetvklldytekplyenlrdillq
glkaigskddgkldl

Timeline for d6npnc_:

• d6npnc_ is new in SCOPe 2.07-stable
  
• d6npnc_ appears in the current release, SCOPe 2.08