SCOPe 2.07: Domain d5xsuc1: 5xsu C:1-135

Lineage for d5xsuc1 (5xsu C:1-135)

1. Root: SCOPe 2.07

2. Class a: All alpha proteins [46456] (289 folds)

3. Fold a.41: Domain of poly(ADP-ribose) polymerase [47586] (1 superfamily)
   core: 4 helices: bundle; unusual topology

4. Superfamily a.41.1: Domain of poly(ADP-ribose) polymerase [47587] (2 families)
   duplication: consists of 2 helix-loop-helix structural repeats
   automatically mapped to Pfam PF02877

5. Family a.41.1.0: automated matches [227223] (1 protein)
   not a true family

6. Protein automated matches [226964] (2 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [225405] (61 PDB entries)

8. Domain d5xsuc1: 5xsu C:1-135 [351566]
   Other proteins in same PDB: d5xsua2, d5xsub2, d5xsuc2, d5xsud2
   automated match to d4hhyd1
   complexed with 8e3, so4

Details for d5xsuc1

PDB Entry: 5xsu, 2.4 Å

PDB Description: novel orally efficacious inhibitors complexed with parp1

PDB Compounds: (C:) Poly [ADP-ribose] polymerase 1

SCOPe Domain Sequences for d5xsuc1:

Sequence, based on SEQRES records:

>d5xsuc1 a.41.1.0 (C:1-135) automated matches {Human (Homo sapiens) [TaxId: 9606]}
ksklpkpvqdlikmifdvesmkkamveyeidlqkmplgklskrqiqaaysilsevqqavs
qgssdsqildlsnrfytliphdfgmkkppllnnadsvqakaemldnlldievaysllrgg
sddsskdpidvnyek

Sequence, based on observed residues (ATOM records):

>d5xsuc1 a.41.1.0 (C:1-135) automated matches {Human (Homo sapiens) [TaxId: 9606]}
ksklpkpvqdlikmifdvesmkkamveyeidlqkmplgklskrqiqaaysilsevqqavl
snrfytliphdppllnnadsvqakaemldnlldievaysllrgsskdpidvnyek

Timeline for d5xsuc1:

• d5xsuc1 is new in SCOPe 2.07-stable
  
• d5xsuc1 appears in the current release, SCOPe 2.08