SCOPe 2.07: Domain d6asqb_: 6asq B:

Lineage for d6asqb_ (6asq B:)

1. Root: SCOPe 2.07

2. Class d: Alpha and beta proteins (a+b) [53931] (388 folds)

3. Fold d.122: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase [55873] (1 superfamily)
   8-stranded mixed beta-sheet; 2 layers: alpha/beta

4. Superfamily d.122.1: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase [55874] (5 families)

5. Family d.122.1.1: Heat shock protein 90, HSP90, N-terminal domain [55875] (2 proteins)

6. Protein HSP90 [55876] (3 species)

7. Species Dog (Canis familiaris) [TaxId:9615] [103225] (35 PDB entries)
   Uniprot P41148 76-285; Endoplasmin, GRP94

8. Domain d6asqb_: 6asq B: [351115]
   automated match to d1qyha_
   complexed with gol, pe8, peg, vc4

Details for d6asqb_

PDB Entry: 6asq, 2.35 Å

PDB Description: structure of grp94 bound to methyl 2-[2-(2-benzylpyridin-3-yl)ethyl]- 3-chloro-4,6-dihydroxybenzoate, a pan-hsp90 inhibitor

PDB Compounds: (B:) Endoplasmin

SCOPe Domain Sequences for d6asqb_:

Sequence, based on SEQRES records:

>d6asqb_ d.122.1.1 (B:) HSP90 {Dog (Canis familiaris) [TaxId: 9615]}
ekfafqaevnrmmkliinslyknkeiflrelisnasdaldkirlisltdenalagneelt
vkikcdkeknllhvtdtgvgmtreelvknlgtiaksgtseflnkmteaqedgqstselig
qfgvgfysaflvadkvivtskhnndtqhiwesdsnefsviadprgntlgrgttitlvlke
easdyleldtiknlvkkysqfinfpiyvwssktggggktvwdwelmn

Sequence, based on observed residues (ATOM records):

>d6asqb_ d.122.1.1 (B:) HSP90 {Dog (Canis familiaris) [TaxId: 9615]}
ekfafqaevnrmmkliinslyknkeiflrelisnasdaldkirlisltdenalagneelt
vkikcdkeknllhvtdtgvgmtreelvknlgtiaksgtseflnkmteastseligqfgvg
fysaflvadkvivtskhnndtqhiwesdsnefsviadprgntlgrgttitlvlkeeasdy
leldtiknlvkkysqfinfpiyvwssktktvwdwelmn

Timeline for d6asqb_:

• d6asqb_ is new in SCOPe 2.07-stable
  
• d6asqb_ appears in the current release, SCOPe 2.08