SCOPe 2.07: Domain d5whrb_: 5whr B:

Lineage for d5whrb_ (5whr B:)

1. Root: SCOPe 2.07

2. Class a: All alpha proteins [46456] (289 folds)

3. Fold a.266: Indolic compounds 2,3-dioxygenase-like [140958] (1 superfamily)
   multihelical; bundle, contains interrupted helices

4. Superfamily a.266.1: Indolic compounds 2,3-dioxygenase-like [140959] (3 families)
   contains heme-dependent enzymes

5. Family a.266.1.2: Indoleamine 2,3-dioxygenase-like [140963] (3 proteins)
   Pfam PF01231; contains extra N-terminal all-alpha subdomain of similar fold to the GST C-terminal domain (47615)

6. Protein automated matches [190585] (2 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187592] (47 PDB entries)

8. Domain d5whrb_: 5whr B: [348134]
   automated match to d5wmxa_
   complexed with aoj, hem

Details for d5whrb_

PDB Entry: 5whr, 2.28 Å

PDB Description: discovery of a novel and selective ido-1 inhibitor pf-06840003 and its characterization as a potential clinical candidate.

PDB Compounds: (B:) Indoleamine 2,3-dioxygenase 1

SCOPe Domain Sequences for d5whrb_:

Sequence, based on SEQRES records:

>d5whrb_ a.266.1.2 (B:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
skeyhideevgfalpnpqenlpdfyndwmfiakhlpdliesgqlrerveklnmlsidhlt
dhksqrlarlvlgcitmayvwgkghgdvrkvlprniavpycqlskklelppilvyadcvl
anwkkkdpnkpltyenmdvlfsfrdgdcskgfflvsllveiaaasaikviptvfkamqmq
erdtllkalleiasclekalqvfhqihdhvnpkaffsvlriylsgwkgnpqlsdglvyeg
fwedpkefaggsagqssvfqcfdvllgiqqtaggghaaqflqdmrrymppahrnflcsle
snpsvrefvlskgdaglreaydacvkalvslrsyhlqivtkyilipasqqpkenktsedp
skleakgtggtdlmnflktvrstteksllk

Sequence, based on observed residues (ATOM records):

>d5whrb_ a.266.1.2 (B:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
skeyhideevgfalpnpqenlpdfyndwmfiakhlpdliesgqlrerveklnmlsidhlt
dhksqrlarlvlgcitmayvwgkghgdvrkvlprniavpycqlskklelppilvyadcvl
anwkkkdpnkpltyenmdvlfsfrdgdcskgfflvsllveiaaasaikviptvfkamqmq
erdtllkalleiasclekalqvfhqihdhvnpkaffsvlriylsgwkgnpqlsdglvyeg
fwedpkefaggsagqssvfqcfdvllgiqqtaggghaaqflqdmrrymppahrnflcsle
snpsvrefvlskgdaglreaydacvkalvslrsyhlqivtkyilipasqkgtggtdlmnf
lktvrstteksllk

Timeline for d5whrb_:

• d5whrb_ is new in SCOPe 2.07-stable
  
• d5whrb_ appears in the current release, SCOPe 2.08