SCOPe 2.08: Domain d3jb9a3: 3jb9 A:823-1604

Lineage for d3jb9a3 (3jb9 A:823-1604)

1. Root: SCOPe 2.08

2. Class e: Multi-domain proteins (alpha and beta) [56572] (74 folds)

3. Fold e.8: DNA/RNA polymerases [56671] (1 superfamily)
   divided into morphological domains including "palm", "thumb" and "fingers"; the catalytic "palm" domain is conserved to all members

4. Superfamily e.8.1: DNA/RNA polymerases [56672] (9 families)
   "palm" domain has a ferredoxin-like fold, related to that of an adenylyl cyclase domain

5. Family e.8.1.8: Splicing factor Prp8 RT domain [345981] (2 proteins)
   Pfam PF10598, Pfam PF10597. Includes linker domain discussed in PubMed 23354046
   Homology to retroviral RT domains discussed in PubMed 21441348

6. Protein Pre-mRNA splicing factor 8, Prp8 / Spp42 [346115] (2 species)

7. Species Schizosaccharomyces pombe 972h- [TaxId:284812] [346407] (1 PDB entry)

8. Domain d3jb9a3: 3jb9 A:823-1604 [344794]
   Other proteins in same PDB: d3jb9a1, d3jb9a2, d3jb9a4, d3jb9a5, d3jb9b1, d3jb9b2, d3jb9b3, d3jb9b4, d3jb9b5, d3jb9c_, d3jb9e_, d3jb9f_, d3jb9g_, d3jb9h_, d3jb9i_, d3jb9j_, d3jb9k_, d3jb9l_, d3jb9m_, d3jb9r_, d3jb9s1, d3jb9s2, d3jb9t1, d3jb9t2, d3jb9u1, d3jb9u2, d3jb9u3, d3jb9v1, d3jb9v2, d3jb9w_, d3jb9x1, d3jb9x2, d3jb9x3, d3jb9x4, d3jb9y1, d3jb9y2, d3jb9z_
   protein/RNA complex; complexed with adp, gdp, mg, zn

Details for d3jb9a3

PDB Entry: 3jb9, 3.6 Å

PDB Description: cryo-em structure of the yeast spliceosome at 3.6 angstrom resolution

PDB Compounds: (A:) Pre-mRNA-splicing factor spp42

SCOPe Domain Sequences for d3jb9a3:

Sequence, based on SEQRES records:

>d3jb9a3 e.8.1.8 (A:823-1604) Pre-mRNA splicing factor 8, Prp8 / Spp42 {Schizosaccharomyces pombe 972h- [TaxId: 284812]}
yvtadeavaiyttfvhwlesrrfqpipfpplsykhdtkllvlalerlkeaysvkgrlnqs
qreelalveqaydnphemlsqikrrlltmrtfkevgiefmdmyshlipvysvdpmekicd
ayldqylwfeadrrhlfpswvkpsdsepppllvykwcqginnltdvwetsngecnvlmet
rlskvfekvdltllnrlmsllmdtnlasyasaknnvvlsykdmshtnsyglvrglqfssf
iwqfyglvldllilglqrateiagpadapndflhfkdqatetshpirlytryidkvyimf
rftdeesrdliqrflnenpdptnsnvvnyskgkkncwprdarmrlmkhdvnlgravfwei
rnrlprslttlewedtfpsvyskdnpnllfsmtgfevrilpkirqneefslkdgvwnltd
nrtkqrtaqafirvtedginqfgnrirqilmssgsttftkiankwntalialmtyyreaa
istpelldllvkceskiqtrvkislnskmpsrfppavfyspkelgglgmlsmghvlipqs
dlrwskqtdtgithfrsgmttngehlipnlyryiqpwesefidsqrvwaeyamkrqealq
qnrrltledledswdrgiprintlfqkdrhtlaydkgwrvrtefkqyqllknnpfwwtsq
rhdgklwqlnnyrvdviqalggvegilehtmfkatgfpsweglfwekasgfeesmkfkkl
tnaqrsglnqipnrrftlwwsptinranvyvgfqvqldltgimmhgkiptlkisliqifr
sh

Sequence, based on observed residues (ATOM records):

>d3jb9a3 e.8.1.8 (A:823-1604) Pre-mRNA splicing factor 8, Prp8 / Spp42 {Schizosaccharomyces pombe 972h- [TaxId: 284812]}
yvtadeavaiyttfvhwlesrrfqpipfpplsykhdtkllvlalerlkeaysvkgrlnqs
qreelalveqaydnphemlsqikrrlltmrtfkevgiefmdmyshlipvysvdpmekicd
ayldqylwfeadrrhlfpswvkpsdsepppllvykwcqginnltdvwetsngecnvlmet
rlskvfekvdltllnrlmsllmdtnlasyasaknnvvlsykdmshtnsyglvrglqfssf
iwqfyglvldllilglqrateiagpadapndflhfkdqatetshpirlytryidkvyimf
rftdeesrdliqrflnenpdptnsnvvnyskgkkncwprdarmrlmkhdvnlgravfwei
rnrlprslttlewedtfpsvyskdnpnllfsmtgfevrilpkirqneefslkdgvwnltd
nrtkqrtaqafirvtedginqfgnrirqilmssgsttftkiankwntalialmtyyreaa
istpelldllvkceskiqtrvkislnskmpsrfppavfyspkelgglgmlsmghvlipqs
dlrwskqtdtgithfrsgmttngehlipnlyryiqpwesefidsqrvwaeyamkrqealq
qnrrltledledswdrgiprintlfqkdrhtlaydkgwrvrtefkqyqllknnpfwwtsq
rhdgklwqlnnyrvdviqalggvegilehtmfkatgfpsweglfwekasgfkkltnaqrs
glnqipnrrftlwwsptinranvyvgfqvqldltgimmhgkiptlkisliqifrsh

Timeline for d3jb9a3:

• d3jb9a3 first appeared in SCOPe 2.07