SCOPe 2.07: Domain d5o12a_: 5o12 A:

Lineage for d5o12a_ (5o12 A:)

1. Root: SCOPe 2.07

2. Class d: Alpha and beta proteins (a+b) [53931] (388 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Proto-oncogene serine/threonine-protein kinase Pim-1 [118133] (1 species)
   OPK group(?); PIM subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [118134] (110 PDB entries)
   Uniprot P11309 33-305 ! Uniprot P11309 32-308

8. Domain d5o12a_: 5o12 A: [340908]
   automated match to d3d7ta_
   complexed with 1ro, imd

Details for d5o12a_

PDB Entry: 5o12, 2.4 Å

PDB Description: crystal structure of pim1 kinase in complex with small-molecule inhibitor

PDB Compounds: (A:) Serine/threonine-protein kinase pim-1

SCOPe Domain Sequences for d5o12a_:

Sequence, based on SEQRES records:

>d5o12a_ d.144.1.7 (A:) Proto-oncogene serine/threonine-protein kinase Pim-1 {Human (Homo sapiens) [TaxId: 9606]}
lesqyqvgpllgsggfgsvysgirvsdnlpvaikhvekdrisdwgelpngtrvpmevvll
kkvssgfsgvirlldwferpdsfvlilerpepvqdlfdfitergalqeelarsffwqvle
avrhchncgvlhrdikdenilidlnrgelklidfgsgallkdtvytdfdgtrvysppewi
ryhryhgrsaavwslgillydmvcgdipfehdeeiirgqvffrqrvssecqhlirwclal
rpsdrptfeeiqnhpwmqdvllpqetaeihlh

Sequence, based on observed residues (ATOM records):

>d5o12a_ d.144.1.7 (A:) Proto-oncogene serine/threonine-protein kinase Pim-1 {Human (Homo sapiens) [TaxId: 9606]}
lesqyqvgpllgssvysgirvsdnlpvaikhvekdrisdwgelptrvpmevvllkkvssg
fsgvirlldwferpdsfvlilerpepvqdlfdfitergalqeelarsffwqvleavrhch
ncgvlhrdikdenilidlnrgelklidfgsgallkdtvytdfdgtrvysppewiryhryh
grsaavwslgillydmvcgdipfehdeeiirgqvffrqrvssecqhlirwclalrpsdrp
tfeeiqnhpwmqdvllpqetaeihlh

Timeline for d5o12a_:

• d5o12a_ first appeared in SCOPe 2.06
  
• d5o12a_ appears in the current release, SCOPe 2.08