SCOPe 2.07: Domain d5w5ol_: 5w5o L:

Lineage for d5w5ol_ (5w5o L:)

1. Root: SCOPe 2.07

2. Class d: Alpha and beta proteins (a+b) [53931] (388 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.0: automated matches [191359] (1 protein)
   not a true family

6. Protein automated matches [190417] (35 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187294] (1319 PDB entries)

8. Domain d5w5ol_: 5w5o L: [340653]
   automated match to d5ar5b_
   complexed with 9xa

Details for d5w5ol_

PDB Entry: 5w5o, 2.89 Å

PDB Description: identification of potent and selective ripk2 inhibitors for the treatment of inflammatory diseases.

PDB Compounds: (L:) receptor-interacting serine/threonine-protein kinase 2

SCOPe Domain Sequences for d5w5ol_:

Sequence, based on SEQRES records:

>d5w5ol_ d.144.1.0 (L:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
aicsalptipyhkladlrylsrgasgtvssarhadwrvqvavkhlhihtplldserkdvl
reaeilhkarfsyilpilgicnepeflgivteympngslnellhrkteypdvawplrfri
lheialgvnylhnmtppllhhdlktqnilldnefhvkiadfglskwrmmslsqsrssksa
peggtiiymppenyepgqksrasikhdiysyavitwevlsrkqpfedvtnplqimysvsq
ghrpvineeslpydiphrarmisliesgwaqnpderpsflkclielepvlrtfeeitfle
aviqlk

Sequence, based on observed residues (ATOM records):

>d5w5ol_ d.144.1.0 (L:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
aicsalptipyhkladlrylsrgasgtvssarhadwrvqvavkhserkdvlreaeilhka
rfsyilpilgicnepeflgivteympngslnellhrkteypdvawplrfrilheialgvn
ylhnmtppllhhdlktqnilldnefhvkiadfglskwrmgtiiymppenyepikhdiysy
avitwevlsrkqpfedvtnplqimysvsqghrpvineeslpydiphrarmisliesgwaq
npderpsflkclielepvlrtfeeitfleaviqlk

Timeline for d5w5ol_:

• d5w5ol_ first appeared in SCOPe 2.06
  
• d5w5ol_ appears in the current release, SCOPe 2.08