SCOPe 2.07: Domain d4zogb_: 4zog B:

Lineage for d4zogb_ (4zog B:)

1. Root: SCOPe 2.07

2. Class d: Alpha and beta proteins (a+b) [53931] (388 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein automated matches [190091] (20 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [188447] (892 PDB entries)

8. Domain d4zogb_: 4zog B: [322793]
   automated match to d3kf4a_
   complexed with mes, mxe, vx6

Details for d4zogb_

PDB Entry: 4zog, 2.3 Å

PDB Description: vx-680/mk-0457 binds to human abl1 also in inactive dfg conformations.

PDB Compounds: (B:) Tyrosine-protein kinase ABL1

SCOPe Domain Sequences for d4zogb_:

Sequence, based on SEQRES records:

>d4zogb_ d.144.1.7 (B:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
kwemertditmkhklgggqygevyegvwkkysltvavktlkedtmeveeflkeaavmkei
khpnlvqllgvctreppfyiitefmtygnlldylrecnrqevnavvllymatqissamey
lekknfihrdlaarnclvgenhlvkvadfglsrlmtgdtytahagakfpikwtapeslay
nkfsiksdvwafgvllweiatygmspypgidlsqvyellekdyrmerpegcpekvyelmr
acwqwnpsdrpsfaeihqafetmfqessis

Sequence, based on observed residues (ATOM records):

>d4zogb_ d.144.1.7 (B:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
kwemertditmkhklgggqygevyegvwkkysltvavktlkedtmeveeflkeaavmkei
khpnlvqllgvctreppfyiitefmtygnlldylrecnrqevnavvllymatqissamey
lekknfihrdlaarnclvgenhlvkvadfglsrlmtgdtytagakfpikwtapeslaynk
fsiksdvwafgvllweiatygmspypgidlsqvyellekdyrmerpegcpekvyelmrac
wqwnpsdrpsfaeihqafetmfqessis

Timeline for d4zogb_:

• d4zogb_ first appeared in SCOPe 2.06
  
• d4zogb_ appears in the current release, SCOPe 2.08