SCOPe 2.04: Domain d2hpp.1: 2hpp L:,H:

Lineage for d2hpp.1 (2hpp L:,H:)

1. Root: SCOPe 2.04

2. Class b: All beta proteins [48724] (176 folds)

3. Fold b.47: Trypsin-like serine proteases [50493] (1 superfamily)
   barrel, closed; n=6, S=8; greek-key
   duplication: consists of two domains of the same fold

4. Superfamily b.47.1: Trypsin-like serine proteases [50494] (5 families)

5. Family b.47.1.2: Eukaryotic proteases [50514] (48 proteins)

6. Protein Thrombin [50531] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [50532] (169 PDB entries)
   Uniprot P00734 331-361,364-421 ! Uniprot P00734 334-360 364-510 518-619 ! Uniprot P00734 328-620 ! Uniprot P00734 355-621 ! Uniprot P00734 328-620

8. Domain d2hpp.1: 2hpp L:,H: [26194]
   Other proteins in same PDB: d2hppp_
   complexed with 0g7

Details for d2hpp.1

PDB Entry: 2hpp, 3.3 Å

PDB Description: Structures of the noncovalent complexes of human and bovine prothrombin fragment 2 with human ppack-thrombin

PDB Compounds: (H:) ALPHA-THROMBIN heavy chain, (L:) ALPHA-THROMBIN light chain

SCOPe Domain Sequences for d2hpp.1:

Sequence, based on SEQRES records:

>g2hpp.1 b.47.1.2 (L:,H:) Thrombin {Human (Homo sapiens) [TaxId: 9606]}
geadcglrplfekksledkterellesyidXivegsdaeigmspwqvmlfrkspqellcg
aslisdrwvltaahcllyppwdknftendllvrigkhsrtryerniekismlekiyihpr
ynwrenldrdialmklkkpvafsdyihpvclpdretaasllqagykgrvtgwgnlketwt
anvgkgqpsvlqvvnlpiverpvckdstriritdnmfcagykpdegkrgdacegdsggpf
vmkspfnnrwyqmgivswgegcdrdgkygfythvfrlkkwiqkvidqf

Sequence, based on observed residues (ATOM records):

>g2hpp.1 b.47.1.2 (L:,H:) Thrombin {Human (Homo sapiens) [TaxId: 9606]}
geadcglrplfekksledkterellesyidXivegsdaeigmspwqvmlfrkspqellcg
aslisdrwvltaahcllyppwdknftendllvrigkhsrtryerniekismlekiyihpr
ynwrenldrdialmklkkpvafsdyihpvclpdretaasllqagykgrvtgwgnlketwg
qpsvlqvvnlpiverpvckdstriritdnmfcagykpdegkrgdacegdsggpfvmkspf
nnrwyqmgivswgegcdrdgkygfythvfrlkkwiqkvidqf

Timeline for d2hpp.1:

• d2hpp.1 first appeared (with stable ids) in SCOP 1.55
  
• d2hpp.1 appears in SCOPe 2.03
  
• d2hpp.1 appears in SCOPe 2.05
  
• d2hpp.1 appears in the current release, SCOPe 2.08