SCOPe 2.04: Domain d4pyva_: 4pyv A:

Lineage for d4pyva_ (4pyv A:)

1. Root: SCOPe 2.04

2. Class b: All beta proteins [48724] (176 folds)

3. Fold b.50: Acid proteases [50629] (1 superfamily)
   barrel, closed; n=6, S=10, complex topology

4. Superfamily b.50.1: Acid proteases [50630] (4 families)

5. Family b.50.1.2: Pepsin-like [50646] (11 proteins)
   duplication: consists of two similar barrel domains
   N-terminal: barrel, partly opened; n*=6, S*=10

6. Protein Chymosin (synonym: renin) [50667] (3 species)

7. Species Human (Homo sapiens) [TaxId:9606] [50669] (62 PDB entries)

8. Domain d4pyva_: 4pyv A: [260230]
   automated match to d2rena_
   complexed with 2xf, dms, nag, so4

Details for d4pyva_

PDB Entry: 4pyv, 2.65 Å

PDB Description: crystal structure of renin in complex with compound4

PDB Compounds: (A:) renin

SCOPe Domain Sequences for d4pyva_:

Sequence, based on SEQRES records:

>d4pyva_ b.50.1.2 (A:) Chymosin (synonym: renin) {Human (Homo sapiens) [TaxId: 9606]}
lgnttssviltnymdtqyygeigigtppqtfkvvfdtgssnvwvpsskcsrlytacvyhk
lfdasdsssykhngteltlrystgtvsgflsqdiitvggitvtqmfgevtempalpfmla
efdgvvgmgfieqaigrvtpifdniisqgvlkedvfsfyynrdsensqslggqivlggsd
pqhyegnfhyinliktgvwqiqmkgvsvgsstllcedgclalvdtgasyisgstssiekl
mealgakkrlfdyvvkcnegptlpdisfhlggkeytltsadyvfqesysskklctlaiha
mdippptgptwalgatfirkfytefdrrnnrigfalar

Sequence, based on observed residues (ATOM records):

>d4pyva_ b.50.1.2 (A:) Chymosin (synonym: renin) {Human (Homo sapiens) [TaxId: 9606]}
lgnttssviltnymdtqyygeigigtppqtfkvvfdtgssnvwvpsskcsrlytacvyhk
lfdasdsssykhngteltlrystgtvsgflsqdiitvggitvtqmfgevtempalpfmla
efdgvvgmgfieqaigrvtpifdniisqgvlkedvfsfyynrdsqslggqivlggsdpqh
yegnfhyinliktgvwqiqmkgvsvgsstllcedgclalvdtgasyisgstssieklmea
lgakkrlfdyvvkcnegptlpdisfhlggkeytltsadyvfqesysskklctlaihamdi
ppptgptwalgatfirkfytefdrrnnrigfalar

Timeline for d4pyva_:

• d4pyva_ is new in SCOPe 2.04-stable
  
• d4pyva_ appears in SCOPe 2.05
  
• d4pyva_ appears in the current release, SCOPe 2.08