SCOPe 2.04: Domain d4oq5f_: 4oq5 F:

Lineage for d4oq5f_ (4oq5 F:)

1. Root: SCOPe 2.04

2. Class f: Membrane and cell surface proteins and peptides [56835] (57 folds)

3. Fold f.1: Toxins' membrane translocation domains [56836] (5 superfamilies)
   multi-helical domains of various folds which is thought to unfold in the membrane

4. Superfamily f.1.4: Bcl-2 inhibitors of programmed cell death [56854] (2 families)
   PROVISIONAL CLASSIFICATION, based on structural similarity to the diphtheria toxin domain

5. Family f.1.4.1: Bcl-2 inhibitors of programmed cell death [56855] (11 proteins)
   Pfam PF00452

6. Protein automated matches [190236] (3 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [188722] (34 PDB entries)

8. Domain d4oq5f_: 4oq5 F: [240724]
   automated match to d4oq5b_
   complexed with 2uu

Details for d4oq5f_

PDB Entry: 4oq5, 2.86 Å

PDB Description: Crystal Structure of Human MCL-1 Bound to Inhibitor 4-(4-methylnaphthalen-1-yl)-2-{[(4-phenoxyphenyl)sulfonyl]amino}benzoic acid

PDB Compounds: (F:) Induced myeloid leukemia cell differentiation protein Mcl-1

SCOPe Domain Sequences for d4oq5f_:

Sequence; same for both SEQRES and ATOM records:

>d4oq5f_ f.1.4.1 (F:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
mdlyrqsleiisrylreqatgakdtkpmgrsgatsrkaletlrrvgdgvqrnhetafqgm
lrkldikneddvkslsrvmihvfsdgvtnwgrivtlisfgafvakhlktinqesciepla
esitdvlvrtkrdwlvkqrgwdgfveffh

Timeline for d4oq5f_:

• d4oq5f_ is new in SCOPe 2.04-stable
  
• d4oq5f_ appears in SCOPe 2.05
  
• d4oq5f_ appears in the current release, SCOPe 2.08, called d4oq5f1