SCOPe 2.07: Domain d4mm4a_: 4mm4 A:

Lineage for d4mm4a_ (4mm4 A:)

1. Root: SCOPe 2.07

2. Class f: Membrane and cell surface proteins and peptides [56835] (60 folds)

3. Fold f.54: SNF-like [161069] (1 superfamily)
   12 transmembrane helices; duplication: consists of two structurally similar halves

4. Superfamily f.54.1: SNF-like [161070] (1 family)

5. Family f.54.1.1: SNF-like [161071] (2 proteins)
   Pfam PF00209; Sodium:neurotransmitter symporter

6. Protein Na(+):neurotransmitter symporter homologue LeuT [161072] (1 species)

7. Species Aquifex aeolicus [TaxId:63363] [161073] (43 PDB entries)
   Uniprot O67854 5-513

8. Domain d4mm4a_: 4mm4 A: [228414]
   automated match to d3f3ea_
   complexed with 8pr, cl, na; mutant

Details for d4mm4a_

PDB Entry: 4mm4, 2.89 Å

PDB Description: Crystal structure of LeuBAT (delta13 mutant) in complex with paroxetine

PDB Compounds: (A:) Transporter

SCOPe Domain Sequences for d4mm4a_:

Sequence, based on SEQRES records:

>d4mm4a_ f.54.1.1 (A:) Na(+):neurotransmitter symporter homologue LeuT {Aquifex aeolicus [TaxId: 63363]}
rehwatrlglilamagyavdlgnflrfpvqaaengggafmipyiiafllvgiplmwiewa
mgryggaqghgttpaifyllwrnrfakilgvfglwiplvvasyyvyieswtlgfaikflv
glvpepppnatdpdsilrpfkeflysyigvpkgdepilkpslfayivflitmfinvsili
rgiskgierfakiamptlfilavflvirvflletpngtaadglnflwtpdfeklkdpgvw
iaavgqiffslglgfgvlitfasyvrkdqdivlsgltaatlnekasvilggsisipaava
ffgvanavaiakagafnlgfitlpaifsqtaggtflgflwffllffagltssiagmqgmi
afledelklsrkhavlwtaaivffsahlvmflnksldemdfwatgigvvffglteliiff
wifgadkaweeinrggiikvpriyyyvmryitpaflavllvvwareyipkimeethwtvw
itrfyiiglflfltflvflaerrrnhe

Sequence, based on observed residues (ATOM records):

>d4mm4a_ f.54.1.1 (A:) Na(+):neurotransmitter symporter homologue LeuT {Aquifex aeolicus [TaxId: 63363]}
rehwatrlglilamagyavdlgnflrfpvqaaengggafmipyiiafllvgiplmwiewa
mgryggaqghgttpaifyllwrnrfakilgvfglwiplvvasyyvyieswtlgfaikflv
glvpepptdpdsilrpfkeflysyigvpkgdepilkpslfayivflitmfinvsilirgi
skgierfakiamptlfilavflvirvflletpngtaadglnflwtpdfeklkdpgvwiaa
vgqiffslglgfgvlitfasyvrkdqdivlsgltaatlnekasvilggsisipaavaffg
vanavaiakagafnlgfitlpaifsqtaggtflgflwffllffagltssiagmqgmiafl
edelklsrkhavlwtaaivffsahlvmflnksldemdfwatgigvvffglteliiffwif
gadkaweeinrggiikvpriyyyvmryitpaflavllvvwareythwtvwitrfyiiglf
lfltflvflaerrrnhe

Timeline for d4mm4a_:

• d4mm4a_ first appeared in SCOPe 2.03
  
• d4mm4a_ appears in SCOPe 2.06
  
• d4mm4a_ appears in the current release, SCOPe 2.08