SCOPe 2.04: Domain d4b05a_: 4b05 A:

Lineage for d4b05a_ (4b05 A:)

1. Root: SCOPe 2.04

2. Class b: All beta proteins [48724] (176 folds)

3. Fold b.50: Acid proteases [50629] (1 superfamily)
   barrel, closed; n=6, S=10, complex topology

4. Superfamily b.50.1: Acid proteases [50630] (4 families)

5. Family b.50.1.2: Pepsin-like [50646] (11 proteins)
   duplication: consists of two similar barrel domains
   N-terminal: barrel, partly opened; n*=6, S*=10

6. Protein beta-secretase (memapsin) [50671] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [50672] (242 PDB entries)
   Uniprot P56817 58-446 ! Uniprot P56817 60-447

8. Domain d4b05a_: 4b05 A: [219234]
   automated match to d4di2a_
   complexed with 32d, act, na

Details for d4b05a_

PDB Entry: 4b05, 1.8 Å

PDB Description: preclinical characterization of azd3839, a novel clinical candidate bace1 inhibitor for the treatment of alzheimer disease

PDB Compounds: (A:) Beta-secretase 1

SCOPe Domain Sequences for d4b05a_:

Sequence, based on SEQRES records:

>d4b05a_ b.50.1.2 (A:) beta-secretase (memapsin) {Human (Homo sapiens) [TaxId: 9606]}
kgsfvemvdnlrgksgqgyyvemtvgsppqtlnilvdtgssnfavgaaphpflhryyqrq
lsstyrdlrkgvyvpytqgkwegelgtdlvsiphgpnvtvraniaaitesdkffingsnw
egilglayaeiarpddslepffdslvkqthvpnlfslqlcgagfplnqsevlasvggsmi
iggidhslytgslwytpirrewyyeviivrveingqdlkmdckeynydksivdsgttnlr
lpkkvfeaavksikaasstekfpdgfwlgeqlvcwqagttpwnifpvislylmgevtnqs
fritilpqqylrpvedvatsqddcykfaisqsstgtvmgavimegfyvvfdrarkrigfa
vsachvhdefrtaavegpfvtldmedcgy

Sequence, based on observed residues (ATOM records):

>d4b05a_ b.50.1.2 (A:) beta-secretase (memapsin) {Human (Homo sapiens) [TaxId: 9606]}
kgsfvemvdnlrgksgqgyyvemtvgsppqtlnilvdtgssnfavgaaphpflhryyqrq
lsstyrdlrkgvyvpyqgkwegelgtdlvsiphgpnvtvraniaaitesdkffingsnwe
gilglayaeiarpddslepffdslvkqthvpnlfslqlcgggsmiiggidhslytgslwy
tpirrewyyeviivrveingqdlkmdckeynydksivdsgttnlrlpkkvfeaavksika
asstekfpdgfwlgeqlvcwqagttpwnifpvislylmgevtnqsfritilpqqylrpve
dvatsqddcykfaisqsstgtvmgavimegfyvvfdrarkrigfavsachdefrtaaveg
pfvtlmedcgy

Timeline for d4b05a_:

• d4b05a_ first appeared in SCOPe 2.03
  
• d4b05a_ appears in SCOPe 2.05
  
• d4b05a_ appears in the current release, SCOPe 2.08