SCOPe 2.04: Domain d3dpda1: 3dpd A:143-321

Lineage for d3dpda1 (3dpd A:143-321)

1. Root: SCOPe 2.04

2. Class d: Alpha and beta proteins (a+b) [53931] (380 folds)

3. Fold d.15: beta-Grasp (ubiquitin-like) [54235] (14 superfamilies)
   core: beta(2)-alpha-beta(2); mixed beta-sheet 2143

4. Superfamily d.15.1: Ubiquitin-like [54236] (9 families)

5. Family d.15.1.5: Ras-binding domain, RBD [54263] (14 proteins)
   contains Pfam PF00788 and Pfam PF02196

6. Protein Phoshoinositide 3-kinase (PI3K) [54274] (2 species)
   includes parts of the flanking linkers

7. Species Human (Homo sapiens) [TaxId:9606] [54276] (57 PDB entries)

8. Domain d3dpda1: 3dpd A:143-321 [209250]
   Other proteins in same PDB: d3dpda2, d3dpda3, d3dpda4
   automated match to d1e8ya3
   complexed with 41a

Details for d3dpda1

PDB Entry: 3dpd, 2.85 Å

PDB Description: Achieving multi-isoform PI3K inhibition in a series of substituted 3,4-Dihydro-2H-benzo[1,4]oxazines

PDB Compounds: (A:) phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

SCOPe Domain Sequences for d3dpda1:

Sequence, based on SEQRES records:

>d3dpda1 d.15.1.5 (A:143-321) Phoshoinositide 3-kinase (PI3K) {Human (Homo sapiens) [TaxId: 9606]}
mseesqafqrqltaligydvtdvsnvhddeleftrrglvtprmaevasrdpklyamhpwv
tskplpeylwkkianncifivihrsttsqtikvspddtpgailqsfftkmakkkslmdip
esqseqdfvlrvcgrdeylvgetpiknfqwvrhclkngeeihvvldtppdpaldevrke

Sequence, based on observed residues (ATOM records):

>d3dpda1 d.15.1.5 (A:143-321) Phoshoinositide 3-kinase (PI3K) {Human (Homo sapiens) [TaxId: 9606]}
mseesqafqrqltaligydvtdvsnvhddeleftrrglvtprmaevasrdpklyamhpwv
tskplpeylwkkianncifivihrsttsqtikvspddtpgailqsfftkmdfvlrvcgrd
eylvgetpiknfqwvrhclkngeeihvvldtppdpaldevrke

Timeline for d3dpda1:

• d3dpda1 first appeared in SCOPe 2.03
  
• d3dpda1 appears in SCOPe 2.05
  
• d3dpda1 appears in the current release, SCOPe 2.08