SCOPe 2.04: Domain d2hz4b_: 2hz4 B:

Lineage for d2hz4b_ (2hz4 B:)

1. Root: SCOPe 2.04

2. Class d: Alpha and beta proteins (a+b) [53931] (380 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Abelsone tyrosine kinase (abl) [56166] (2 species)
   PTK group; Abl subfamily; non-membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [226825] (5 PDB entries)

8. Domain d2hz4b_: 2hz4 B: [204669]
   automated match to d2e2ba_
   complexed with 4st

Details for d2hz4b_

PDB Entry: 2hz4, 2.8 Å

PDB Description: abl kinase domain unligated and in complex with tetrahydrostaurosporine

PDB Compounds: (B:) Proto-oncogene tyrosine-protein kinase ABL1

SCOPe Domain Sequences for d2hz4b_:

Sequence, based on SEQRES records:

>d2hz4b_ d.144.1.7 (B:) Abelsone tyrosine kinase (abl) {Human (Homo sapiens) [TaxId: 9606]}
dkwemertditmkhklgggqygevyegvwkkysltvavktlkedtmeveeflkeaavmke
ikhpnlvqllgvctreppfyiitefmtygnlldylrecnrqevnavvllymatqissame
ylekknfihrdlaarnclvgenhlvkvadfglsrlmtgdtytahagakfpikwtapesla
ynkfsiksdvwafgvllweiatygmspypgidlsqvyellekdyrmerpegcpekvyelm
racwqwnpsdrpsfaeihqafetmfq

Sequence, based on observed residues (ATOM records):

>d2hz4b_ d.144.1.7 (B:) Abelsone tyrosine kinase (abl) {Human (Homo sapiens) [TaxId: 9606]}
dkwemertditmkhklgevyegvwkkysltvavktlkedtmeveeflkeaavmkeikhpn
lvqllgvctreppfyiitefmtygnlldylrecnrqevnavvllymatqissameylekk
nfihrdlaarnclvgenhlvkvadfglsrlmtgdtytahagakfpikwtapeslaynkfs
iksdvwafgvllweiatygmspypgidlsqvyellekdyrmerpegcpekvyelmracwq
wnpsdrpsfaeihqafetmfq

Timeline for d2hz4b_:

• d2hz4b_ first appeared in SCOPe 2.03
  
• d2hz4b_ appears in SCOPe 2.05
  
• d2hz4b_ appears in the current release, SCOPe 2.08, called d2hz4b1