SCOPe 2.07: Domain d4eoqa1: 4eoq A:1-297

Lineage for d4eoqa1 (4eoq A:1-297)

1. Root: SCOPe 2.07

2. Class d: Alpha and beta proteins (a+b) [53931] (388 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Cyclin-dependent PK, CDK2 [88855] (2 species)
   CMGC group; CDKs subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [88856] (413 PDB entries)
   Uniprot P24941

8. Domain d4eoqa1: 4eoq A:1-297 [201919]
   Other proteins in same PDB: d4eoqa2, d4eoqb1, d4eoqb2, d4eoqc2, d4eoqd1, d4eoqd2
   automated match to d4eoqc_
   complexed with atp, mg, sgm

Details for d4eoqa1

PDB Entry: 4eoq, 2.15 Å

PDB Description: Thr 160 phosphorylated CDK2 WT - human cyclin A3 complex with ATP

PDB Compounds: (A:) cyclin-dependent kinase 2

SCOPe Domain Sequences for d4eoqa1:

Sequence, based on SEQRES records:

>d4eoqa1 d.144.1.7 (A:1-297) Cyclin-dependent PK, CDK2 {Human (Homo sapiens) [TaxId: 9606]}
menfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllkelnh
pnivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafchs
hrvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgckyy
stavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykpsf
pkwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphlr

Sequence, based on observed residues (ATOM records):

>d4eoqa1 d.144.1.7 (A:1-297) Cyclin-dependent PK, CDK2 {Human (Homo sapiens) [TaxId: 9606]}
menfqkvekigegtygvvykarnkltgevvalkkirltegvpstaireisllkelnhpni
vklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafchshrv
lhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgckyysta
vdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykpsfpkw
arqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphlr

Timeline for d4eoqa1:

• d4eoqa1 first appeared in SCOPe 2.03, called d4eoqa_
  
• d4eoqa1 appears in SCOPe 2.06
  
• d4eoqa1 appears in the current release, SCOPe 2.08