SCOPe 2.03: Domain d1a2ya_: 1a2y A:

Lineage for d1a2ya_ (1a2y A:)

1. Root: SCOPe 2.03

2. Class b: All beta proteins [48724] (174 folds)

3. Fold b.1: Immunoglobulin-like beta-sandwich [48725] (28 superfamilies)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands

4. Superfamily b.1.1: Immunoglobulin [48726] (5 families)

5. Family b.1.1.1: V set domains (antibody variable domain-like) [48727] (33 proteins)

6. Protein Immunoglobulin light chain kappa variable domain, VL-kappa [88519] (16 species)
   VL-kappa domains of human and mouse antibodies are clustered by the sequence similarity within the germline encoded segment and then by the size of the complementarity determining regions CDR1 and CDR2, so the clusters may correspond to putative germline families in the species genomes; VL-kappa domains with artificial or grafted exogenous CDRs are listed as engineered species

7. Species Mouse (Mus musculus), cluster 4 [TaxId:10090] [88531] (213 PDB entries)
   Uniprot P01645 1-106 # 95% sequense identity; KV5L_MOUSE Ig kappa chain V-V region HP 93G7 ! SQ NA # natural chimera; best hits are: Uniprot P01637 (Ig kappa chain V-V region T1) and Uniprot P01837 (Ig kappa chain C region) ! SQ NA # humanized antibody ! SQ NA # part of Fab 28 against HIV-1 RT ! Uniprot P01642 21-115 # ! KV5I_MOUSE Ig kappa chain V-V region L7 precursor

8. Domain d1a2ya_: 1a2y A: [19926]
   Other proteins in same PDB: d1a2yb_, d1a2yc_
   part of Fv D1.3
   complexed with po4; mutant

Details for d1a2ya_

PDB Entry: 1a2y, 1.5 Å

PDB Description: hen egg white lysozyme, d18a mutant, in complex with mouse monoclonal antibody d1.3

PDB Compounds: (A:) igg1-kappa d1.3 fv (light chain)

SCOPe Domain Sequences for d1a2ya_:

Sequence; same for both SEQRES and ATOM records:

>d1a2ya_ b.1.1.1 (A:) Immunoglobulin light chain kappa variable domain, VL-kappa {Mouse (Mus musculus), cluster 4 [TaxId: 10090]}
divltqspaslsasvgetvtitcrasgnihnylawyqqkqgkspqllvyytttladgvps
rfsgsgsgtqyslkinslqpedfgsyycqhfwstprtfgggtkleik

Timeline for d1a2ya_:

• d1a2ya_ first appeared (with stable ids) in SCOP 1.55
  
• d1a2ya_ appears in SCOPe 2.02
  
• d1a2ya_ appears in SCOPe 2.04
  
• d1a2ya_ appears in the current release, SCOPe 2.08