SCOPe 2.04: Domain d3osib_: 3osi B:

Lineage for d3osib_ (3osi B:)

1. Root: SCOPe 2.04

2. Class a: All alpha proteins [46456] (285 folds)

3. Fold a.123: Nuclear receptor ligand-binding domain [48507] (1 superfamily)
   multihelical; 3 layers or orthogonally packed helices

4. Superfamily a.123.1: Nuclear receptor ligand-binding domain [48508] (2 families)

5. Family a.123.1.1: Nuclear receptor ligand-binding domain [48509] (34 proteins)

6. Protein Peroxisome proliferator activated receptor gamma, PPAR-gamma [48524] (1 species)
7. Species Human (Homo sapiens) [TaxId:9606] [48525] (85 PDB entries)
   Uniprot P37231 232-505

8. Domain d3osib_: 3osi B: [183268]
   automated match to d1nyxa_
   complexed with pgo, xdh

Details for d3osib_

PDB Entry: 3osi, 2.7 Å

PDB Description: crystal structure of ppargamma ligand binding domain in complex with tetrachloro-bisphenol a (tcbpa)

PDB Compounds: (B:) Peroxisome proliferator-activated receptor gamma

SCOPe Domain Sequences for d3osib_:

Sequence, based on SEQRES records:

>d3osib_ a.123.1.1 (B:) Peroxisome proliferator activated receptor gamma, PPAR-gamma {Human (Homo sapiens) [TaxId: 9606]}
sadlralakhlydsyiksfpltkakarailtgkttdkspfviydmnslmmgedkikfkhi
tplqeqskevairifqgcqfrsveavqeiteyaksipgfvnldlndqvtllkygvheiiy
tmlaslmnkdgvlisegqgfmtreflkslrkpfgdfmepkfefavkfnalelddsdlaif
iaviilsgdrpgllnvkpiediqdnllqalelqlklnhpessqlfakllqkmtdlrqivt
ehvqllqvikktetdmslhpllqeiyk

Sequence, based on observed residues (ATOM records):

>d3osib_ a.123.1.1 (B:) Peroxisome proliferator activated receptor gamma, PPAR-gamma {Human (Homo sapiens) [TaxId: 9606]}
sadlralakhlydsyiksfpltkakarailtgkspfviydmnslmmgedkkevairifqg
cqfrsveavqeiteyaksipgfvnldlndqvtllkygvheiiytmlaslmnkdgvliseg
qgfmtreflkslrkpfgdfmepkfefavkfnalelddsdlaifiaviilsgdrpgllnvk
piediqdnllqalelqlklnhpessqlfakllqkmtdlrqivtehvqllqvikktehpll
qeiyk

Timeline for d3osib_:

• d3osib_ first appeared in SCOPe 2.01
  
• d3osib_ appears in SCOPe 2.03
  
• d3osib_ appears in SCOPe 2.05
  
• d3osib_ appears in the current release, SCOPe 2.08