SCOPe 2.07: Domain d3efjb_: 3efj B:

Lineage for d3efjb_ (3efj B:)

1. Root: SCOPe 2.07

2. Class d: Alpha and beta proteins (a+b) [53931] (388 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Hepatocyte growth factor receptor, c-MET [103300] (1 species)
   PTK group; HGFR subfamily; membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [103301] (58 PDB entries)

8. Domain d3efjb_: 3efj B: [174911]
   automated match to d1r0pa_
   complexed with mt3

Details for d3efjb_

PDB Entry: 3efj, 2.6 Å

PDB Description: structure of c-met with pyrimidone inhibitor 7

PDB Compounds: (B:) Hepatocyte growth factor receptor

SCOPe Domain Sequences for d3efjb_:

Sequence, based on SEQRES records:

>d3efjb_ d.144.1.7 (B:) Hepatocyte growth factor receptor, c-MET {Human (Homo sapiens) [TaxId: 9606]}
dlsalnpelvqavqhvvigpsslivhfnevigrghfgcvyhgtlldndgkkihcavksln
ritdigevsqfltegiimkdfshpnvlsllgiclrsegsplvvlpymkhgdlrnfirnet
hnptvkdligfglqvakgmkylaskkfvhrdlaarncmldekftvkvadfglardmydke
yysvhnktgaklpvkwmaleslqtqkfttksdvwsfgvllwelmtrgappypdvntfdit
vyllqgrrllqpeycpdplyevmlkcwhpkaemrpsfselvsrisaifstfigehyvh

Sequence, based on observed residues (ATOM records):

>d3efjb_ d.144.1.7 (B:) Hepatocyte growth factor receptor, c-MET {Human (Homo sapiens) [TaxId: 9606]}
dlsalnpelvqavqhvvigpsslivhfnevigrghfgcvyhgtlldndgkkihcavksln
ritdigevsqfltegiimkdfshpnvlsllgiclrsegsplvvlpymkhgdlrnfirnet
hnptvkdligfglqvakgmkylaskkfvhrdlaarncmldekftvkvadpvkwmaleslq
tqkfttksdvwsfgvllwelmtrgappypdvntfditvyllqgrrllqpeycpdplyevm
lkcwhpkaemrpsfselvsrisaifstfigehyvh

Timeline for d3efjb_:

• d3efjb_ first appeared in SCOPe 2.01
  
• d3efjb_ appears in SCOPe 2.06
  
• d3efjb_ appears in the current release, SCOPe 2.08