SCOPe 2.07: Domain d3dgac_: 3dga C:

Lineage for d3dgac_ (3dga C:)

1. Root: SCOPe 2.07

2. Class d: Alpha and beta proteins (a+b) [53931] (388 folds)

3. Fold d.117: Thymidylate synthase/dCMP hydroxymethylase [55830] (1 superfamily)
   contains large mixed beta-sheet

4. Superfamily d.117.1: Thymidylate synthase/dCMP hydroxymethylase [55831] (2 families)
   automatically mapped to Pfam PF00303

5. Family d.117.1.1: Thymidylate synthase/dCMP hydroxymethylase [55832] (4 proteins)

6. Protein automated matches [190469] (17 species)
   not a true protein

7. Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [188759] (2 PDB entries)

8. Domain d3dgac_: 3dga C: [173920]
   Other proteins in same PDB: d3dgaa_, d3dgab_
   automated match to d1j3ic_
   complexed with ndp, rj1, ump

Details for d3dgac_

PDB Entry: 3dga, 2.7 Å

PDB Description: wild-type plasmodium falciparum dihydrofolate reductase-thymidylate synthase (pfdhfr-ts) complexed with rjf01302, nadph, and dump

PDB Compounds: (C:) Bifunctional dihydrofolate reductase-thymidylate synthase

SCOPe Domain Sequences for d3dgac_:

Sequence; same for both SEQRES and ATOM records:

>d3dgac_ d.117.1.1 (C:) automated matches {Malaria parasite (Plasmodium falciparum) [TaxId: 5833]}
deeeddfvyfnfnkekeeknknsihpndfqiynslkykyhpeyqylniiydimmngnkqs
drtgvgvlskfgyimkfdlsqyfpllttkklflrgiieellwfirgetngntllnknvri
weangtrefldnrklfhrevndlgpiygfqwrhfgaeytnmydnyenkgvdqlkniinli
kndptsrrillcawnvkdldqmalppchilcqfyvfdgklscimyqrscdlglgvpfnia
sysifthmiaqvcnlqpaqfihvlgnahvynnhidslkiqlnripypfptlklnpdikni
edftisdftiqnyvhhekismdmaa

Timeline for d3dgac_:

• d3dgac_ first appeared in SCOPe 2.01
  
• d3dgac_ appears in SCOPe 2.06
  
• d3dgac_ appears in the current release, SCOPe 2.08