SCOPe 2.07: Domain d3cpcb_: 3cpc B:

Lineage for d3cpcb_ (3cpc B:)

1. Root: SCOPe 2.07

2. Class d: Alpha and beta proteins (a+b) [53931] (388 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Vascular endothelial growth factor receptor 2 (kdr) [56160] (1 species)
   PTK group; PDGFR/VEGFR subfamily; membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [56161] (25 PDB entries)

8. Domain d3cpcb_: 3cpc B: [173390]
   Other proteins in same PDB: d3cpca2
   automated match to d1vr2a_
   complexed with c52

Details for d3cpcb_

PDB Entry: 3cpc, 2.4 Å

PDB Description: crystal structure of the vegfr2 kinase domain in complex with a pyridone inhibitor

PDB Compounds: (B:) Vascular endothelial growth factor receptor 2

SCOPe Domain Sequences for d3cpcb_:

Sequence, based on SEQRES records:

>d3cpcb_ d.144.1.7 (B:) Vascular endothelial growth factor receptor 2 (kdr) {Human (Homo sapiens) [TaxId: 9606]}
lpydaskwefprdrlklgkplgrgafgqvieadafgidktatcrtvavkmlkegathseh
ralmselkilihighhlnvvnllgactkpggplmvitefckfgnlstylrskrnefvpyk
vapedlykdfltlehlicysfqvakgmeflasrkcihrdlaarnillseknvvkicdfgl
ardiykdpdyvrkgdarlplkwmapetifdrvytiqsdvwsfgvllweifslgaspypgv
kideefcrrlkegtrmrapdyttpemyqtmldcwhgepsqrptfselvehlgnllq

Sequence, based on observed residues (ATOM records):

>d3cpcb_ d.144.1.7 (B:) Vascular endothelial growth factor receptor 2 (kdr) {Human (Homo sapiens) [TaxId: 9606]}
lpydaskwefprdrlklgkplgqvieadafgidktatcrtvavkmlathsehralmselk
ilihighhlnvvnllgactkpggplmvitefckfgnlstylrskrnefvpykdfltlehl
icysfqvakgmeflasrkcihrdlaarnillseknvvkicdfglplkwmapetifdrvyt
iqsdvwsfgvllweifslgaspypgvkideefcrrlkegtrmrapdyttpemyqtmldcw
hgepsqrptfselvehlgnllq

Timeline for d3cpcb_:

• d3cpcb_ first appeared in SCOPe 2.01
  
• d3cpcb_ appears in SCOPe 2.06
  
• d3cpcb_ appears in the current release, SCOPe 2.08