SCOPe 2.08: Domain d2qaba_: 2qab A:

Lineage for d2qaba_ (2qab A:)

1. Root: SCOPe 2.08

2. Class a: All alpha proteins [46456] (290 folds)

3. Fold a.123: Nuclear receptor ligand-binding domain [48507] (1 superfamily)
   multihelical; 3 layers or orthogonally packed helices

4. Superfamily a.123.1: Nuclear receptor ligand-binding domain [48508] (2 families)

5. Family a.123.1.1: Nuclear receptor ligand-binding domain [48509] (34 proteins)

6. Protein Estrogen receptor alpha [48519] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [48520] (107 PDB entries)
   Uniprot P03372 307-551

8. Domain d2qaba_: 2qab A: [167492]
   automated match to d1qkua_
   complexed with ei1; mutant

Details for d2qaba_

PDB Entry: 2qab, 1.89 Å

PDB Description: crystal structure of estrogen receptor alpha ligand binding domain mutant 537s complexed with an ethyl indazole compound

PDB Compounds: (A:) Estrogen receptor

SCOPe Domain Sequences for d2qaba_:

Sequence, based on SEQRES records:

>d2qaba_ a.123.1.1 (A:) Estrogen receptor alpha {Human (Homo sapiens) [TaxId: 9606]}
slalsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhminwakrv
pgfvdltlhdqvhllecawleilmiglvwrsmehpgkllfapnllldrnqgkcvegmvei
fdmllatssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdhihrvldkitd
tlihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmkcknvvplsdllleml
dahr

Sequence, based on observed residues (ATOM records):

>d2qaba_ a.123.1.1 (A:) Estrogen receptor alpha {Human (Homo sapiens) [TaxId: 9606]}
slalsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhminwakrv
pgfvdltlhdqvhllecawleilmiglvwrsmehpgkllfapnllldrnqgkcvegmvei
fdmllatssrfrmmnlqgeefvclksiillnsgvytfeekdhihrvldkitdtlihlmak
agltlqqqhqrlaqlllilshirhmsnkgmehlysmkcknvvplsdlllemldahr

Timeline for d2qaba_:

• d2qaba_ first appeared in SCOPe 2.01
  
• d2qaba_ appears in SCOPe 2.07