SCOPe 2.03: Domain d2q7la_: 2q7l A:

Lineage for d2q7la_ (2q7l A:)

1. Root: SCOPe 2.03

2. Class a: All alpha proteins [46456] (284 folds)

3. Fold a.123: Nuclear receptor ligand-binding domain [48507] (1 superfamily)
   multihelical; 3 layers or orthogonally packed helices

4. Superfamily a.123.1: Nuclear receptor ligand-binding domain [48508] (2 families)

5. Family a.123.1.1: Nuclear receptor ligand-binding domain [48509] (34 proteins)

6. Protein Androgen receptor [63621] (4 species)

7. Species Human (Homo sapiens) [TaxId:9606] [63623] (45 PDB entries)
   Uniprot P10275 671-919

8. Domain d2q7la_: 2q7l A: [167463]
   automated match to d1e3ga_
   complexed with gol, tes; mutant

Details for d2q7la_

PDB Entry: 2q7l, 1.92 Å

PDB Description: the androgen receptor prostate cancer mutant h874y ligand binding domain bound with testosterone and a tif2 box3 coactivator peptide 740-753

PDB Compounds: (A:) Androgen receptor

SCOPe Domain Sequences for d2q7la_:

Sequence, based on SEQRES records:

>d2q7la_ a.123.1.1 (A:) Androgen receptor {Human (Homo sapiens) [TaxId: 9606]}
piflnvleaiepgvvcaghdnnqpdsfaallsslnelgerqlvhvvkwakalpgfrnlhv
ddqmaviqyswmglmvfamgwrsftnvnsrmlyfapdlvfneyrmhksrmysqcvrmrhl
sqefgwlqitpqeflcmkalllfsiipvdglknqkffdelrmnyikeldriiackrknpt
scsrrfyqltklldsvqpiarelyqftfdllikshmvsvdfpemmaeiisvqvpkilsgk
vkpiyfhtq

Sequence, based on observed residues (ATOM records):

>d2q7la_ a.123.1.1 (A:) Androgen receptor {Human (Homo sapiens) [TaxId: 9606]}
piflnvleaiepgvvcaghdnnqpdsfaallsslnelgerqlvhvvkwakalpgfrnlhv
ddqmaviqyswmglmvfamgwrsftnvnsrmlyfapdlvfneyrmhksrmysqcvrmrhl
sqefgwlqitpqeflcmkalllfsiipvdglknqkffdelrmnyikeldriiarknptsc
srrfyqltklldsvqpiarelyqftfdllikshmvsvdfpemmaeiisvqvpkilsgkvk
piyfhtq

Timeline for d2q7la_:

• d2q7la_ first appeared in SCOPe 2.01
  
• d2q7la_ appears in SCOPe 2.02
  
• d2q7la_ appears in SCOPe 2.04
  
• d2q7la_ appears in the current release, SCOPe 2.08