SCOPe 2.03: Domain d2gira_: 2gir A:

Lineage for d2gira_ (2gir A:)

1. Root: SCOPe 2.03

2. Class e: Multi-domain proteins (alpha and beta) [56572] (66 folds)

3. Fold e.8: DNA/RNA polymerases [56671] (1 superfamily)
   divided into morphological domains including "palm", "thumb" and "fingers"; the catalytic "palm" domain is conserved to all members

4. Superfamily e.8.1: DNA/RNA polymerases [56672] (7 families)
   "palm" domain has a ferredoxin-like fold, related to that of an adenylyl cyclase domain

5. Family e.8.1.4: RNA-dependent RNA-polymerase [56694] (3 proteins)

6. Protein Viral RNA polymerase [56695] (16 species)

7. Species Hepatitis c virus (isolate bk) [TaxId:11105] [195056] (4 PDB entries)

8. Domain d2gira_: 2gir A: [164726]
   automated match to d1nb4a_
   complexed with nn3

Details for d2gira_

PDB Entry: 2gir, 1.9 Å

PDB Description: hepatitis c virus rna-dependent rna polymerase ns5b with nni-1 inhibitor

PDB Compounds: (A:) RNA-directed RNA polymerase

SCOPe Domain Sequences for d2gira_:

Sequence, based on SEQRES records:

>d2gira_ e.8.1.4 (A:) Viral RNA polymerase {Hepatitis c virus (isolate bk) [TaxId: 11105]}
hmsytwtgalitpcaaeesklpinalsnsllrhhnmvyattsrsaglrqkkvtfdrlqvl
ddhyrdvlkemkakastvkakllsveeackltpphsakskfgygakdvrnlsskavnhih
svwkdlledtvtpidttimaknevfcvqpekggrkparlivfpdlgvrvcekmalydvvs
tlpqvvmgssygfqyspgqrveflvntwkskknpmgfsydtrcfdstvtendirveesiy
qccdlapearqaikslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkas
aacraaklqdctmlvngddlvvicesagtqedaaslrvfteamtrysappgdppqpeydl
elitscssnvsvahdasgkrvyyltrdpttplaraawetarhtpvnswlgniimyaptlw
armilmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsafslhsyspg
einrvasclrklgvpplrvwrhrarsvrarllsqggraatcgkylfnwavktklkltpip
aasrldlsgwfvagysggdiyh

Sequence, based on observed residues (ATOM records):

>d2gira_ e.8.1.4 (A:) Viral RNA polymerase {Hepatitis c virus (isolate bk) [TaxId: 11105]}
hmsytwtgalitpcaaeesklpinalsnsllrhhnmvyattsrsaglrqkkvtfdrlqvl
ddhyrdvlkemkakastvkakllsveeackltpphsakskfgygakdvrnlsskavnhih
svwkdlledtvtpidttimaknevfcvqrkparlivfpdlgvrvcekmalydvvstlpqv
vmgssygfqyspgqrveflvntwkskknpmgfsydtrcfdstvtendirveesiyqccdl
apearqaikslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkasaacra
aklqdctmlvngddlvvicesagtqedaaslrvfteamtrysappgdppqpeydlelits
cssnvsvahdasgkrvyyltrdpttplaraawetarhtpvnswlgniimyaptlwarmil
mthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsafslhsyspgeinrv
asclrklgvpplrvwrhrarsvrarllsqggraatcgkylfnwavktklkltpipaasrl
dlsgwfvagysggdiyh

Timeline for d2gira_:

• d2gira_ first appeared in SCOPe 2.01
  
• d2gira_ appears in SCOPe 2.02
  
• d2gira_ appears in SCOPe 2.04
  
• d2gira_ appears in the current release, SCOPe 2.08, called d2gira1