SCOPe 2.04: Domain d2bbsb_: 2bbs B:

Lineage for d2bbsb_ (2bbs B:)

1. Root: SCOPe 2.04

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.37: P-loop containing nucleoside triphosphate hydrolases [52539] (1 superfamily)
   3 layers: a/b/a, parallel or mixed beta-sheets of variable sizes

4. Superfamily c.37.1: P-loop containing nucleoside triphosphate hydrolases [52540] (25 families)
   division into families based on beta-sheet topologies

5. Family c.37.1.12: ABC transporter ATPase domain-like [52686] (24 proteins)
   there are two additional subdomains inserted into the central core that has a RecA-like topology

6. Protein Cystic fibrosis transmembrane conductance regulator, CFTR, nucleotide-binding domain [102378] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [117543] (8 PDB entries)
   Uniprot P13569 389-671

8. Domain d2bbsb_: 2bbs B: [163033]
   automated match to d1xmid_
   complexed with atp, mg; mutant

Details for d2bbsb_

PDB Entry: 2bbs, 2.05 Å

PDB Description: human deltaf508 nbd1 with three solubilizing mutations

PDB Compounds: (B:) Cystic fibrosis transmembrane conductance regulator

SCOPe Domain Sequences for d2bbsb_:

Sequence, based on SEQRES records:

>d2bbsb_ c.37.1.12 (B:) Cystic fibrosis transmembrane conductance regulator, CFTR, nucleotide-binding domain {Human (Homo sapiens) [TaxId: 9606]}
ttevvmenvtafweegfgelfekakqnnnnrktsngddslsfsnfsllgtpvlkdinfki
ergqllavagstgagktsllmmimgelepsegkikhsgrisfcsqnswimpgtikeniig
vsydeyryrsvikacqleediskfaekdnivlgeggitlsggqrarislaravykdadly
lldspfgyldvltekeifescvcklmanktrilvtskmehlkkadkililhegssyfygt
fselqnlrpdfssklmgcdsfdqfsaerrnsiltetlhrfs

Sequence, based on observed residues (ATOM records):

>d2bbsb_ c.37.1.12 (B:) Cystic fibrosis transmembrane conductance regulator, CFTR, nucleotide-binding domain {Human (Homo sapiens) [TaxId: 9606]}
ttevvmenvtafwvlkdinfkiergqllavagstgagktsllmmimgelepsegkikhsg
risfcsqnswimpgtikeniigvsydeyryrsvikacqleediskfaekdnivlggitls
ggqrarislaravykdadlylldspfgyldvltekeifescvcklmanktrilvtskmeh
lkkadkililhegssyfygtfselqnlrdsfdqfsaerrnsiltetlhrfs

Timeline for d2bbsb_:

• d2bbsb_ first appeared in SCOPe 2.01
  
• d2bbsb_ appears in SCOPe 2.03
  
• d2bbsb_ appears in SCOPe 2.05
  
• d2bbsb_ appears in the current release, SCOPe 2.08