SCOPe 2.07: Domain d2v22a_: 2v22 A:

Lineage for d2v22a_ (2v22 A:)

1. Root: SCOPe 2.07

2. Class d: Alpha and beta proteins (a+b) [53931] (388 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Cyclin-dependent PK, CDK2 [88855] (2 species)
   CMGC group; CDKs subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [88856] (413 PDB entries)
   Uniprot P24941

8. Domain d2v22a_: 2v22 A: [161560]
   Other proteins in same PDB: d2v22b1, d2v22b2, d2v22d1, d2v22d2
   automated match to d1aq1a_
   complexed with c35

Details for d2v22a_

PDB Entry: 2v22, 2.6 Å

PDB Description: replace: a strategy for iterative design of cyclin binding groove inhibitors

PDB Compounds: (A:) Cell division protein kinase 2

SCOPe Domain Sequences for d2v22a_:

Sequence; same for both SEQRES and ATOM records:

>d2v22a_ d.144.1.7 (A:) Cyclin-dependent PK, CDK2 {Human (Homo sapiens) [TaxId: 9606]}
menfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllkelnh
pnivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafchs
hrvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgckyy
stavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykpsf
pkwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphl

Timeline for d2v22a_:

• d2v22a_ first appeared in SCOPe 2.01
  
• d2v22a_ appears in SCOPe 2.06
  
• d2v22a_ appears in the current release, SCOPe 2.08