SCOPe 2.07: Domain d2qhxd_: 2qhx D:

Lineage for d2qhxd_ (2qhx D:)

1. Root: SCOPe 2.07

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families)

5. Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (71 proteins)
   also known as short-chain dehydrogenases and SDR family
   parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7

6. Protein Dihydropteridin reductase (pteridine reductase) [51769] (7 species)

7. Species Leishmania major [TaxId:5664] [63926] (14 PDB entries)
   Uniprot Q01782

8. Domain d2qhxd_: 2qhx D: [150799]
   Other proteins in same PDB: d2qhxc_
   automated match to d1p33b_
   complexed with fe1, iod, nap

Details for d2qhxd_

PDB Entry: 2qhx, 2.61 Å

PDB Description: structure of pteridine reductase from leishmania major complexed with a ligand

PDB Compounds: (D:) pteridine reductase 1

SCOPe Domain Sequences for d2qhxd_:

Sequence, based on SEQRES records:

>d2qhxd_ c.2.1.2 (D:) Dihydropteridin reductase (pteridine reductase) {Leishmania major [TaxId: 5664]}
tvpvalvtgaakrlgrsiaeglhaegyavclhyhrsaaeanalsatlnarrpnsaitvqa
dlsnvatapvsgadgsapvtlftrcaelvaacythwgrcdvlvnnassfyptpllrnded
ghepcvgdreametatadlfgsnaiapyflikafahrvagtpakhrgtnysiinmvdamt
nqpllgytiytmakgalegltrsaalelaplqirvngvgpglsvlvddmppavweghrsk
vplyqrdssaaevsdvviflcsskakyitgtcvkvdggysltra

Sequence, based on observed residues (ATOM records):

>d2qhxd_ c.2.1.2 (D:) Dihydropteridin reductase (pteridine reductase) {Leishmania major [TaxId: 5664]}
tvpvalvtgaakrlgrsiaeglhaegyavclhyhrsaaeanalsatlnarrpnsaitvqa
dlsnvatapapvtlftrcaelvaacythwgrcdvlvnnassfyptpllrdreametatad
lfgsnaiapyflikafahrvagtpakhrgtnysiinmvdamtnqpllgytiytmakgale
gltrsaalelaplqirvngvgpglsvlveghrskvplyqrdssaaevsdvviflcsskak
yitgtcvkvdggysltra

Timeline for d2qhxd_:

• d2qhxd_ first appeared in SCOP 1.75, called d2qhxd1
  
• d2qhxd_ was called d2qhxd1 in SCOPe 2.06
  
• d2qhxd_ appears in the current release, SCOPe 2.08