SCOPe 2.03: Domain d2oipa2: 2oip A:181-521

Lineage for d2oipa2 (2oip A:181-521)

1. Root: SCOPe 2.03

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.117: Thymidylate synthase/dCMP hydroxymethylase [55830] (1 superfamily)
   contains large mixed beta-sheet

4. Superfamily d.117.1: Thymidylate synthase/dCMP hydroxymethylase [55831] (2 families)
   automatically mapped to Pfam PF00303

5. Family d.117.1.1: Thymidylate synthase/dCMP hydroxymethylase [55832] (4 proteins)

6. Protein Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, TS domain [55841] (2 species)

7. Species Cryptosporidium hominis [TaxId:237895] [100887] (3 PDB entries)

8. Domain d2oipa2: 2oip A:181-521 [148785]
   Other proteins in same PDB: d2oipa1, d2oipb1, d2oipc1, d2oipd1, d2oipe1
   automatically matched to d1qzfa2
   complexed with cb3, mtx, ndp, ump; mutant

Details for d2oipa2

PDB Entry: 2oip, 2.8 Å

PDB Description: crystal structure of the s290g active site mutant of ts-dhfr from cryptosporidium hominis

PDB Compounds: (A:) Chain A, crystal structure of Dhfr

SCOPe Domain Sequences for d2oipa2:

Sequence, based on SEQRES records:

>d2oipa2 d.117.1.1 (A:181-521) Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, TS domain {Cryptosporidium hominis [TaxId: 237895]}
ktlqncdpargqlksiddtvdllgeifgirkmgnrhkfpkeeiyntpsirfgrehyefqy
ldllsrvlengayrenrtgistysifgqmmrfdmresfpllttkkvairgifeeliwfik
gdtngnhliekkvyiwsgngskeyleriglghreendlgpiygfqwrhyngeyktmhddy
tgvgvdqlaklietlknnpkdrrhiltawnpsalsqmalppchvlsqyyvtndnclscnl
yqrscdlglgspfniasyailtmmlaqvcgyepgelaifigdahiyenhltqlkeqlsrt
prpfpqlkfkrkveniedfkwedieligyypyptikmdmav

Sequence, based on observed residues (ATOM records):

>d2oipa2 d.117.1.1 (A:181-521) Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, TS domain {Cryptosporidium hominis [TaxId: 237895]}
kncdpargqlksiddtvdllgeifgirkmgnrhkfpkeeiyntpsirfgrehyefqyldl
lsrvlengayrenrtgistysifgqmmrfdmresfpllttkkvairgifeeliwfikgdt
ngnhliekkvyiwsgngskeyleriglghreendlgpiygfqwrhyngeyktmhddytgv
gvdqlaklietlknnpkdrrhiltawnpsalsqmalppchvlsqyyvtndnclscnlyqr
scdlglgspfniasyailtmmlaqvcgyepgelaifigdahiyenhltqlkeqlsrtprp
fpqlkfkrkveniedfkwedieligyypyptikmdmav

Timeline for d2oipa2:

• d2oipa2 first appeared in SCOP 1.75
  
• d2oipa2 appears in SCOPe 2.02
  
• d2oipa2 appears in SCOPe 2.04
  
• d2oipa2 appears in the current release, SCOPe 2.08