SCOPe 2.07: Family d.294.1.2: Nsp15 C-terminal domain-like

Lineage for Family d.294.1.2: Nsp15 C-terminal domain-like

1. Root: SCOPe 2.07

2. Class d: Alpha and beta proteins (a+b) [53931] (388 folds)

3. Fold d.294: EndoU-like [142876] (1 superfamily)
   comprises several helices and two three-stranded antiparallel beta-sheets; similar architecture to the RNase A-like fold (54075)

4. Superfamily d.294.1: EndoU-like [142877] (3 families)
   similarity to the RNase A-like superfamily (54076) extends to the active site location and architecture; the two structural cores of the RNase A and EndoU superfamilies are interrelated by a topological permutation - transposition of two pereferial beta-strands, suggesting possible distant homology of the two superfamilies (and their unification in a hyperfamily)

5. Family d.294.1.2: Nsp15 C-terminal domain-like [142881] (2 proteins)
   PfamB PB001946

Proteins:

1. Nsp15, C-terminal domain [142882] (2 species)

   1. Species Murine hepatitis virus, MHV [TaxId:11138] [142884] (2 PDB entries)
      Uniprot P16342 6720-6872

   2. Species SARS coronavirus [TaxId:227859] [142883] (3 PDB entries)
      Uniprot Q6VA80 6620-6774

2. automated matches [384919] (1 species)
   not a true protein

   • Species Severe acute respiratory syndrome coronavirus 2 [TaxId:2697049] [384920] (27 PDB entries)

More info for Family d.294.1.2: Nsp15 C-terminal domain-like

Timeline for Family d.294.1.2: Nsp15 C-terminal domain-like:

• Family d.294.1.2: Nsp15 C-terminal domain-like first appeared in SCOP 1.73
  
• Family d.294.1.2: Nsp15 C-terminal domain-like appears in SCOPe 2.06
  
• Family d.294.1.2: Nsp15 C-terminal domain-like appears in the current release, SCOPe 2.08